α-Metalated Isocyanides Toward a Tangible Reagent Space

Dedicated to Ulrich Schöllkopf, the pioneer of a-metalated isocyanide chemistry

Abstract

α-Metalated isocyanides are a versatile class of compounds that can easily be employed in various transformations, affording tangible libraries for screening campaigns. We report the ring-opening reactions of cyclic anhydrides and lactones with three different metalated isocyanides that readily give 4,5-disubstituted oxazoles, including useful drug-like synthetic intermediates with two functional groups as handles for further modifications.

Key words

isocyanides - tosylmethyl isocyanide - oxazoles - anhydrides - lactones

Publication History

Received: 20 June 2022

Accepted after revision: 08 August 2022

Accepted Manuscript online:
08 August 2022

Article published online:
09 September 2022

• References and Notes

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