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DOI: 10.1055/a-2330-0819
Synthesis of Substituted Cyclooctenes through Cross-Coupling Reactions
Cross-coupling methods for the introduction of various substituents into the olefin moiety of cyclooctenes were developed. A range of 1-substituted cis-cyclooctenes were synthesized. These protocols unlocked routes to previously inaccessible derivatives, allowing for the syntheses of cis-cyclooctenes bearing various functional groups. Moreover, the method was applied to the synthesis of a 1,2-disubstituted trans-cyclooctene for the first time, which proved to be a significantly active organocatalyst in relation to the previously developed monosubstituted trans-cyclooctene.
Publication History
Received: 18 April 2024
Accepted after revision: 18 May 2024
Accepted Manuscript online:
18 May 2024
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