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Synthesis
DOI: 10.1055/a-2501-4796
DOI: 10.1055/a-2501-4796
feature
A Revised Protecting Group Strategy enables a Divergent Synthesis of Prenylated Isoflavones from Psoralea corylifolia
Supported by: Deutscher Akademischer Austauschdienst 57381412
Three bioactive prenylated isoflavone natural products were synthesized for the first time, using a combination of Pd-catalyzed Suzuki-Miyaura-coupling for installing the B-ring, microwave promoted Claisen-rearrangement of allyl ethers, and Ru-catalyzed olefin cross metathesis for obtaining the prenyl substituents. Careful consideration of the protecting group strategy turned out to be vital for the success of these total syntheses.
Publication History
Received: 12 November 2024
Accepted after revision: 12 December 2024
Accepted Manuscript online:
12 December 2024
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