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Planta Med 2015; 81(01): 20-25
DOI: 10.1055/s-0034-1383304
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Inhibitory Effect of Oleanolic Acid from the Rhizomes of Cyperus rotundus on Transient Receptor Potential Vanilloid 1 Channel

Joo Hyun Nam
1   Department of Physiology, Dongguk University College of Medicine, Kyungju, Republic of Korea
2   Channelopathy Research Center (CRC), Dongguk University College of Medicine, Goyang, Republic of Korea
,
Dong-Ung Lee
3   Division of Bioscience, Dongguk University, Gyeongju, Republic of Korea
› Author Affiliations
Further Information

Publication History

received 09 July 2014
revised 12 September 2014

accepted 17 October 2014

Publication Date:
17 November 2014 (online)

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Abstract

Cyperus rotundus is used as an analgesic and sedative in oriental medicine and has been reported to exhibit antinociceptive and anti-inflammatory effects. On the other hand, the transient receptor potential vanilloid 1 channel is a nonselective cation channel that senses various noxious chemical and thermal stimuli. However, it has recently been reported that the epidermally expressed transient receptor potential vanilloid 1 channel is involved in heat- and UV-induced skin aging. The aim of this study was to evaluate whether C. rotundus extract and its constituents can inhibit this channel. Ethylacetate and hexane fractions of the methanol extract were found to partially inhibit transient receptor potential vanilloid 1 channel activity, and at a concentration of 90 µM, oleanolic acid, which was one of three constituents isolated from the ethylacetate fraction, inhibited this activity by 61.4 ± 8.0 %. This is first electrophysiological study to be conducted on the effects of C. rotundus extract and its constituents on the transient receptor potential vanilloid 1 channel. The results obtained provide insight of the potential therapeutic effects of C. rotundus in the contexts of analgesia and UV-induced photoaging.

Key words

Cyperus rotundus - Cyperaceae - TRPV1 - oleanolic acid

Supporting Information

 

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