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Planta Med 2015; 81(08): 648-654
DOI: 10.1055/s-0035-1546017
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Effects of the Olive Tree Leaf Constituents on Myocardial Oxidative Damage and Atherosclerosis

Panagiotis Efentakis
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Athens, Greece
,
Efstathios K. Iliodromitis
2   Second Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Athens, Greece
,
Emmanuel Mikros
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Athens, Greece
,
Anastasia Papachristodoulou
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Athens, Greece
,
Nikolaos Dagres
2   Second Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Athens, Greece
,
Alexios-Leandros Skaltsounis
3   Laboratory of Pharmacognocy and Chemistry of Natural Products, Faculty of Pharmacy, University of Athens, Athens, Greece
,
Ioanna Andreadou
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Athens, Greece
› Author Affiliations
Further Information

Publication History

received 04 August 2014
revised 06 April 2015

accepted 07 April 2015

Publication Date:
27 May 2015 (online)

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Abstract

The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effects. The pathogenesis of certain common diseases, including those of the cardiovascular system, involves oxidative stress and tissue inflammation. Olive polyphenolic compounds, such as oleuropein, hydroxytyrosol, or tyrosol, possess antioxidant, anti-inflammatory, antiatherosclerotic, anti-ischemic, and hypolipidemic effects on the myocardium as demonstrated by various in vitro and in vivo studies. In this review article, we summarize the current knowledge on the role of the olive leaf constituents in the prevention of cardiac dysfunction and highlight future perspectives in their use as cardioprotective agents in therapeutics.

Key words

olive leaf constituents - oxidative stress - LDL oxidation - anti-atherosclerotic effects - anti-ischemic effects - Olea europaea - Oleaceae
 

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