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Synlett 1992; 1992(1): 73-76
DOI: 10.1055/s-1992-21271
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Dicobalt Hexacarbonyl Complexes as Chirality Relay for the Differentiation of Acetylenic Diastereomers

Carole Alayrac* , Charles Mioskowski, Jean-Pierre Salaün, Francis Durst
  • *Université Louis Pasteur, Laboratoire de Chimie Bio-Organique associé au CNRS, Faculté de Pharmacie, 74 route du Rhin, BP 24, F-67401 Strasbourg, France
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Publication Date:
18 September 2002 (online)

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Two chiral centers at both ends of an acetylenic bond often lead to two diastereomers that are not distinguishable either by chromatography or by NMR. The complexation of compounds such as 1-substituted 3-(tetrahydropyran-2-yl)-2-propyn-1-ols with octacarbonyl dicobalt at the triple bond discriminates the two isomers and allows their easy differentiation.

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