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Synlett 1992; 1992(7): 573-574
DOI: 10.1055/s-1992-21419
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Enantioselective Addition of Diethylzinc to Aldehydes in the Presence of Chiral Titanium Reagent Modified with N-Sulfonylated Amino Alcohol

Katsuji Ito* , Yasushi Kimura, Hiroaki Okamura, Tsutomu Katsuki
  • *Department of Chemistry, Faculty of Science, Kyushu University 33, Hakozaki, Higashi-ku, Fukuoka 812, Japan
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Publication Date:
08 March 2002 (online)

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Titanium(IV) isopropoxide modified with (1S,2R)-2-(p-methoxyphenylsulfonylamino)-1-phenylpropanol (9), was found to be an effective catalyst for enantioselective addition of diethylzinc to aldehydes. For example, benzaldehyde was converted into (S)-1-phenylpropanol in 97% enantiomeric excess.

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