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Synlett 1993; 1993(8): 605-606
DOI: 10.1055/s-1993-22548
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Asymmetric Dihydroxylation (AD) of α,β-Unsaturated Ketones

Patrick J. Walsh* , K. Barry Sharpless
  • *Department of Chemistry, The Scripps Research Institute, 10666 N. Torrey Pines Road, La Jolla, California 92037, USA
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Publication History

Publication Date:
19 March 2002 (online)

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The asymmetric dihydroxylation of α,β-unsaturated ketones has been investigated and found to give the corresponding α,β-dihydroxy ketones in good yields and excellent enantiomeric excesses. The problem of epimerization of the α-carbon has been eliminated by employing a buffered AD-mix containing sodium bicarbonate.

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