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Horm Metab Res 1986; 18(2): 126-128
DOI: 10.1055/s-2007-1012247
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Islet Cell Antibodies and Other Autoantibodies in South African Blacks and Indians with Insulin Dependent Diabetes Mellitus (IDDM)

M. A. K. Omar1 , G. F. Bottazzo2 , A. C. Asmal3
  • 1Department of Medicine, University of Natal, Congella, South Africa,
  • 2Department of Clinical Immunology, Middlesex Hospital, London, England
  • 3Joslin Clinic and Harward University, Boston, Massachusetts, U.S.A.
Further Information

Publication History

1984

1984

Publication Date:
14 March 2008 (online)

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Summary

The presence or absence of islet cell antibodies and other autoantibodies was determined in 47 African and 34 Indian patients with IDDM and 37 controls. Islet cell antibodies (ICA-IgG) were found in over a third of the patients and in only 2 controls. Complement fixing antibodies (ICA-Cf) were found in 10 % of patients, but in none of the controls. Persistence of ICA beyond 3 years was more frequent in Black compared to Indian patients. Parietal cell antibodies were found more often in patients (20 %) than controls (5 %) as were thyroid microsomal antibodies (11 % vs. 0 %). None of the patients or controls had adrenal antibodies.

Key-Words

Islet Cell Antibodies - Autoantibodies - IDDM - South African Blacks - Indians

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