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DOI: 10.1055/s-2007-979910
© Georg Thieme Verlag Stuttgart · New York
Vagal Modulation of the Insulin Secretory Response to KCl Loading in Nephrectomized Dogs
Publication History
1993
1994
Publication Date:
23 April 2007 (online)
Abstract
In K-loaded intact and nephrectomized control dogs there is a four-to five-fold increase of basal serum insulin. With beta receptor blockade in K-loaded intact animals the increase of basal serum insulin is less than Œ to that in controls; in those with nephrectomy, the increase is similar to that in controls. Cervical vagotomy in K-loaded intact dogs does not alter (influence) the increase of serum insulin; in those with nephrectomy there is a striking increase. In K-loaded intact dogs cervical vagotomy added to beta receptor blockade has no influence i.e., the response is the same as that to blockade alone; in those with nephrectomy, the increase produced by vagotomy is suppressed. Results suggest that in controls with nephrectomy, the insulin secretory response does not involve beta receptors of pancreatic islet B cells owing to restraint by efferent impulses in the cervical vagi. Interruption of the impulse by vagotomy releases the restraint, with resulting hyperactivity; the accompanying hyperinsulinemia may be the result of suppression of the hyperactive receptors by beta receptor blockade.
Key words
Beta Receptor Blockade - Cervical Vagotomy - Efferent Vagal Impulses - Nephrectomy - Pancreatic Islet B Cells