Download PDF
Horm Metab Res 1995; 27(2): 70-75
DOI: 10.1055/s-2007-979911
Originals Basic

© Georg Thieme Verlag Stuttgart · New York

Accelerated Cholesteryl Ester Transfer in Baboons with Insulin-Requiring Diabetes Mellitus

J. D. Bagdade, D. J. Koerker, M. C. Ritter, D. S. Weigle, C. J. Goodner
  • Rush-Presbyterrian-St. Luke's Medical Center, Chicago, Illinois, and Harborview Medical Center, University of Washington Regional Primate Center, Seattle, Washington, U.S.A.
Further Information

Publication History

1994

1994

Publication Date:
23 April 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Cholesteryl ester transfer (CET), plasma, lipoprotein lipid and phospholipid composition were studied in insulin-treated baboons with chronic streptozotocin-induced diabetes. In these diabetic animals, CET measured both as the mass (p < 0.001) and isotopic transfer (p <0.05) of CE from HDL to the apo B-containing lipoproteins (VLDL + LDL) were significantly accelerated compared to controls and the response closely resembled that recently reported in diabetic humans. No significant differences were present in plasma triglyceride, cholesterol, or HDL-C or in lipoprotein core or surface lipid composition. Thus, despite the fact that they did not display the same spectrum of abnormalities in lipoprotein composition, these insulin-treated diabetic baboons demonstrated an abnormality in CET identical to that described in humans. These findings suggest that this non-human primate may provide a suitable diabetic animal model in which to better characterize the mechanisms that underlie this potentially atherogenic disturbance in lipoprotein transport.

Key words

Lipoprotein Composition - Cholesteryl Ester Transfer - Diabetes Mellitus - Animal Model

      >