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Planta Med 1980; 40(9): 77-85
DOI: 10.1055/s-2008-1074944
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Neue herzwirksame Drogen

I: Zur Chemie und Pharmakologie des herzwirksamen Prinzips von Annona squamosaNew drugs with cardiotonic activityI Chemistry and pharmacology of the cardiotonic active principle of Annona squasmosa L.H. Wagner1 , M. Reiter2 , W. Ferstl3
  • 1Institut für Pharmazeutische Arzneimittellehre der Ludwig Maximiliansuniversität
  • 2Institut für Pharmakologie und Toxikologie der Technischen Universität, München
  • 3Abteilung der Pharmakologie der Gesellschaft für Strahlen- und Umweltforschung, München, Bundesrepublik Deutschland
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Publication History

Publication Date:
29 April 2008 (online)

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Abstract

From the leaves of Annona squamosa L. a tetrahydroisoquinoline alkaloid has been isolated and identified as the cardiotonic active principle of the drug. The alkaloid has been structurally elucidated as p-hydroxybenzyl -6,7-dihydroxy- 1, 2, 3, 4-tetrahydro-isoquinoline (demethyl-coclaurine = higenamine). Its positive inotropic activity results from an interaction with the ß-adrenoceptors of the heart muscle.

Key Word Index

Annona squamosa - Annonaceae - Higenamine, Demethyl-coclaurine - Tetrahydroisoquinoline Alkaloid - Positive Inotropic Activity.

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