Z Gastroenterol 2016; 54(12): 1343-1404
DOI: 10.1055/s-0036-1597505
5. Virus Immunology
Georg Thieme Verlag KG Stuttgart · New York

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

V Khairnar
1   University of Duisburg Essen, Institute of Immunology, Medical Faculty, Essen, Germany
,
V Duhan
1   University of Duisburg Essen, Institute of Immunology, Medical Faculty, Essen, Germany
,
JR Göthert
2   University Hospital Essen, Department of Hematology, West German Cancer Center (WTZ), Düsseldorf, Germany
,
PA Lang
2   University Hospital Essen, Department of Hematology, West German Cancer Center (WTZ), Düsseldorf, Germany
,
BB Singer
4   University of Duisburg-Essen, Institute of Anatomy, Medical Faculty, Essen, Germany
,
KS Lang
1   University of Duisburg Essen, Institute of Immunology, Medical Faculty, Essen, Germany
› Author Affiliations
Further Information
Lang, Karl S.

Publication History

Publication Date:
19 December 2016 (online)

Also available at
 
 

    B cells are essential for antiviral immune defense because they produce neutralizing antibodies, present antigen, and maintain the lymphoid architecture. Here we show that intrinsic signaling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence on the proliferation of B cells, expression of CEACAM1 induces survival of proliferating B cells via the BTK/Syk/NF-κB-axis. The absence of this signaling cascade in naive Ceacam1-/- mice limits the survival of B cells. During systemic infection with cytopathic vesicular stomatitis virus, Ceacam1-/- mice can barely induce neutralizing antibody responses and die early after infection. We find, therefore, that CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses.


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    No conflict of interest has been declared by the author(s).

    Lang, Karl S.