CC BY-NC-ND 4.0 · Laryngorhinootologie 2018; 97(S 02): S353-S354
DOI: 10.1055/s-0038-1640944
Abstracts
Rhinologie: Rhinology

The Complement System in CRSwNP

U Werner
1   Klinik für Hals-, Nasen- und Ohrenheilkunde, UKSH, Lübeck
,
R Pries
1   Klinik für Hals-, Nasen- und Ohrenheilkunde, UKSH, Lübeck
,
B Wollenberg
1   Klinik für Hals-, Nasen- und Ohrenheilkunde, UKSH, Lübeck
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    Introduction:

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is widely characterized by a Th2-based chronic inflammation of the nasal and paranasal sinus mucosa in the western population. The complement system is a central part of the innate immune system and tightly regulated. An uncontrolled activation can lead to problematic inflammatory reactions and diseases. Determining variations of complement factors in polyp tissue and evaluate the consequential meaning is therefore subject of this work.

    Methods:

    Polyp and corresponding inferior turbinate tissue from CRSwNP patients and the inferior turbinate from healthy patients were collected surgically. To assess the distribution of various complement factors several molecular biological (microarray, qPCR), biochemical (Western Blot, flow cytometry) and immunohistological (LSAB) methods were used.

    Results:

    The investigations showed alterations in the expression patterns of different complement components in the tissue of CRSwNP patient material compared to healthy controls. Additionally, an enhanced activation of the C3/C3aR-axis in nasal polyps compared to the internal control (corresponding inferior turbinate) could have been determined.

    Conclusions:

    The present data point to an association between an increased complement activation and the chronic inflammatory milieu in CRSwNP, whereas the C3/C3aR-axis is playing a prominent role. These and other findings form the basis for the characterizing the development and maintenance of ongoing inflammatory processes in nasal polyps and are essential for the development of prospective therapy approaches.


    #

    No conflict of interest has been declared by the author(s).

    Prof. Dr. med. Barbara Wollenberg
    Klinik für Hals-, Nasen- und Ohrenheilkunde, UKSH,
    Ratzeburger Allee 160, Haus 2823538,
    Lübeck

    Publication History

    Publication Date:
    18 April 2018 (online)

    © 2018. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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