Thorac Cardiovasc Surg 2019; 67(S 02): S101-S128
DOI: 10.1055/s-0039-1679039
Oral Presentations
Sunday, February 17, 2019
European International Session DGPK/AEPC
Georg Thieme Verlag KG Stuttgart · New York

Gut Inflammation in Fontan Patients Is Associated with Increased Enteric Protein Loss, Augmented Systemic Inflammation, and Alterations in Vitamin D Homeostasis

K. Dam Ten
1   Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, The Netherlands
2   Division of Pediatric Cardiology, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
,
I. Germund
3   Department of Pediatric Cardiology, Heart Center, University Hospital of Cologne University, Cologne, Germany
,
M. Haustein
4   Department of Pediatric Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
M. Khalil
5   Pediatric Heart Center, Justus-Liebig University, Giessen, Germany
,
P. L. Koopman
1   Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, The Netherlands
2   Division of Pediatric Cardiology, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
,
C. Apitz
6   Department of Pediatric Cardiology, University Children’s Hospital Ulm, Ulm, Germany
,
L. T. Duijnhouwer
7   Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands
,
L. E. T. T. Tjwa
8   Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands
,
M. Huntgeburth
9   Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
K. Brockmeier
4   Department of Pediatric Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
A. W. Helbing
2   Division of Pediatric Cardiology, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
10   Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands
,
U. Herberg
11   Department of Pediatric Cardiology, University of Bonn, Bonn, Germany
,
N. Sreeram
4   Department of Pediatric Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
B. R. Tanke
1   Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, The Netherlands
2   Division of Pediatric Cardiology, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
,
G. Kerst
12   Department of Pediatric Cardiology, University Hospital RWTH Aachen, Aachen, Germany
,
A. ten Cate F. E. Udink
2   Division of Pediatric Cardiology, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
10   Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands
› Author Affiliations
Further Information

Publication History

Publication Date:
28 January 2019 (online)

 
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    Objectives: Gut inflammation (GI) has been observed in Fontan patients with protein-losing enteropathy (PLE). The clinical relevance of this finding is unknown. The aim of the present study was to identify factors associated with the presence and severity of IF in a cross-sectional Fontan cohort.

    Methods: A retrospective chart review was performed of Fontan patients who had been screened for both enteric protein loss and presence of GI, by measuring fecal α-1 antitrypsin (A1AT) and fecal calprotectin (FC) levels, respectively. Associations between laboratory parameters (serum albumin level, markers of systemic inflammation, vitamin D metabolism) and clinical characteristics were explored. Patients without ≥ moderate ventricular dysfunction, ≥ moderate valvular regurgitation, cyanosis, or PLE, and classified as NYHA class I were defined as good Fontan. Patients not fulfilling these criteria were classified as failing Fontan.

    Results: From 2011 to 2018, 41 Fontan patients (31.7% female, age 9.3 ± 3.6; PLE: n = 18, 43.9%) were screened. Increased FC levels (> 50 µg/g) were found in 16 patients (39%, PLE n = 10). A strong correlation between FC and A1AT levels was found (r = 0.689, p < 0.0001). This association was independent of having a good Fontan circulation, presence of GI, or PLE (all p < 0.05). GI was found in six Fontan patients without PLE (14.6%). Interestingly, significant enteric protein loss developed in four of these patients (median A1AT 683 µg/g, normal 100–500 µg/g) within 11 to 26 months. This was not seen in Fontan patients without GI. Furthermore, PLE patients with active GI had lower albumin levels, lower lymphocyte count, higher NLR and A1AT than PLE patients with normal FC concentrations (all p < 0.05). Furthermore, strong correlations were found between FC levels, measures of systemic inflammation, serum albumin levels, and markers of vitamin D metabolism in PLE patients, patients with GI, and failing Fontan patients (all p < 0.05), but not in good Fontan patients (all p > 0.1).

    Conclusion: GI seems an emerging mechanism of disease in Fontan, and is strongly associated with severity of enteric protein loss, augmented systemic inflammation, and altered vitamin D metabolism. Future studies are needed to determine whether alterations in intestinal function are responsible for these findings.


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    No conflict of interest has been declared by the author(s).

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