Nuklearmedizin 2019; 58(02): 114
DOI: 10.1055/s-0039-1683498
Vorträge
Demenz und Neuroonkologie
Georg Thieme Verlag KG Stuttgart · New York

Striatal dopamine deficiency is associated with increased striatal glucose metabolism in Dementia with Lewy Bodies

L Beyer
1   Klinikum der Universität München, Klinik und Poliklinik für Nuklearmedizin, München
,
M Huber
1   Klinikum der Universität München, Klinik und Poliklinik für Nuklearmedizin, München
,
S Morbelli
2   Department of Health Sciences, University of Genoa, Nuclear Medicine Unit, Genoa
,
M Unterrainer
1   Klinikum der Universität München, Klinik und Poliklinik für Nuklearmedizin, München
,
A Chincarini
3   National Institute of Nuclear Physics (INFN), Genoa section, Genoa
,
R Buffaerts
4   Faculty of Medicine, KU Leuven, Department of Neurosciences, Leuven
,
MG Kramberger
5   University Medical Centre, Department of Neurology, Ljubljana
,
M Grmek
6   University Medical Centre, Ljubljana, Department for Nuclear Medicine, Ljubljana
,
V Garibotto
7   Geneva University Hospitals and NIMTLab, Division of Nuclear Medicine and Molecular Imaging, Geneva
,
N Nicastro
8   University of Cambridge, Department of Psychiatry, Cambridge
,
GB Frisoni
9   Geneva University Hospitals, Laboratoire de Neuroimagerie du Vieillissement, Geneva
,
A Pilotto
10   University of Brescia, Neurology Unit, Brescia
,
S Garcia-Ptacek
11   Karolinska Institutet, Center for Alzheimer Research, Stockholm
,
I Savitcheva
12   Karolinska Institutet, Department of Radiology, Stockholm
,
MA Ochoa-Figueroa
13   Linköping University Hospital, Department of Clinical Physiology, Linköping
,
V Camacho
14   Universitat Autònoma de Barcelona, Servicio de Medicina Nuclear, Barcelona
,
D Aarsland
15   Stavanger University Hospital, Centre for Age-Related Medicine, Stavanger
,
P Bartenstein
1   Klinikum der Universität München, Klinik und Poliklinik für Nuklearmedizin, München
,
A Rominger
16   Inselspital Bern, Universitätsklinik für Nuklearmedizin, Bern
,
M Brendel
1   Klinikum der Universität München, Klinik und Poliklinik für Nuklearmedizin, München
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
27. März 2019 (online)

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    Ziel/Aim:

    Striatal dopamine deficiency is a well-known phenomenon in Dementia with Lewy Bodies (DLB) and can be quantified in vivo by 123I-FP-CIT SPECT (DaTSCAN®). DLB is further characterized by metabolic decline in distinct brain regions as assessible by 18F-FDG-PET. However, the role of striatal glucose metabolism and its linkage to dopamine deficiency in the pathophysiological course of DLB is not sufficiently understood yet. Hence, we made use of the hitherto largest dataset of combined DaTSCAN® and FDG-PET data in DLB deriving from the European DLB consortium (E-DLB) to elucidate the striatal glucose metabolism during disease progression.

    Methodik/Methods:

    We analysed 162 DLB patients of the European DLB consortium which all had an available FDG-PET and 68 had an available DaTSCAN®. Striatal glucose metabolism normalized by global mean was analyzed as a function of disease duration. Dopamine deficiency was correlated with metabolic changes in the striatum. Finally, we used the striatal quantification of FDG-PET and DaTSCAN® for a voxel-based correlation analysis with FDG-PET to study dopamine-metabolic and metabolic-metabolic connectivity. All data were controlled for center, age, gender, and educational level.

    Ergebnisse/Results:

    Striatal glucose metabolism increased with disease duration in DLB (R = 0.19, p = 0.02). We observed a strong association of dopamine deficiency with increased glucose metabolism in the striatum (R = 0.55, p < 0.001). Striatal dopamine deficiency and increased striatal glucose metabolism showed similar negative connectivity with parietal and occipital cortical areas and positive connectivity with the limbic system.

    Schlussfolgerungen/Conclusions:

    Combined analysis of metabolic changes and dopamine deficiency in DLB indicates a strong interrelation of both biomarkers. Increased striatal metabolism may act as a compensatory function of dopamine deficiency and connectivity analyses of subcortical and cortical systems will allow further insight in the pathophysiology of DLB.


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