Nuklearmedizin 2019; 58(02): 142-143
DOI: 10.1055/s-0039-1683583
Vorträge
Schilddrüse
Georg Thieme Verlag KG Stuttgart · New York

Multispectral Optoacoustic Tomography (MSOT): A Novel Label-Free Imaging Technique for Thyroid Imaging

M Krönke
1   Klinikum rechts der Isar, Klinik und Poliklinik für Nuklearmedizin, München
,
A Karlas
2   Klinikum rechts der Isar, Lehrstuhl für medizinische Bildgebung, München
,
N Fasoula
2   Klinikum rechts der Isar, Lehrstuhl für medizinische Bildgebung, München
,
NA Markwardt
2   Klinikum rechts der Isar, Lehrstuhl für medizinische Bildgebung, München
,
M Kallmayer
3   Klinikum rechts der Isar, Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie, München
,
H Eckstein
3   Klinikum rechts der Isar, Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie, München
,
K Scheidhauer
1   Klinikum rechts der Isar, Klinik und Poliklinik für Nuklearmedizin, München
,
W Weber
1   Klinikum rechts der Isar, Klinik und Poliklinik für Nuklearmedizin, München
,
V Ntziachristos
2   Klinikum rechts der Isar, Lehrstuhl für medizinische Bildgebung, München
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2019 (online)

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    Ziel/Aim:

    MSOT is a novel imaging technique that can provide morphological and functional tissue characterization without the need for contrast agents. Tissue is illuminated by laser pulses and ultrasound signals are produced and then collected to form high-resolution tomographic images. We explore the capabilities of MSOT to characterize functional changes of the thyroid parenchyma in patients with Graves' disease and autonomous adenomas.

    Methodik/Methods:

    In this ongoing prospective study, we have enrolled 8 volunteers and 10 patients (8 f, 2 m, age: 20 – 78 y, median 54.5, 5 Graves' disease, 5 autonomous adenomas). Levels of oxy- and deoxy-hemoglobin (hb), total blood volume, local oxygen saturation (sO2) as well as lipid and water content were extracted. For data analysis, different standard and advanced image reconstruction techniques were applied: backprojection and model-based reconstruction, deconvolution with electrical and spatial impulse response, use of ultrasound priors, linear unmixing and spectral tissue characterization.

    Ergebnisse/Results:

    So far, model-based reconstructions without deconvolution seem to offer highest imaging accuracy and contrast. The use of ultrasound priors might help improve image quality by noise reduction. Adenomas and Graves' disease showed increased oxy- and deoxy-hb when compared to normal thyroid (in arbitrary units (au); oxy: 8.6, 12, 7.7 au, p < 0.01; deoxy: 5.5, 7.9, 4.9 au, p < 0.05), increased perfusion – as confirmed by Doppler-ultrasound- (15, 20, 12 au, p < 0.05), as well as decreased sO2 (0.54, 0.56, 0.58, p < 0.05). No differences in fat or water content were found.

    Schlussfolgerungen/Conclusions:

    MSOT of the thyroid can provide a variety of functional parameters in a single imaging session. Since MSOT is non-invasive and does not require ionizing radiation, this new technology shows significant potential for studies of thyroid pathophysiology in various disease.


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