Nuklearmedizin 2019; 58(02): 162
DOI: 10.1055/s-0039-1683642
Poster
Bewegungsstörungen und Epilepsie
Georg Thieme Verlag KG Stuttgart · New York

Performance evaluation of multi-pinhole collimators for dopamine transporter SPECT

K Tecklenburg
1   University Medical Center Hamburg-Eppendorf, Department for Diagnostic and Interventional Radiology and Nuclear Medicine, Hamburg, Germany
,
A Forgács
2   University of Debrecen, Department of Medical Imaging, Debrecen, Hungary
,
L Göpfert
1   University Medical Center Hamburg-Eppendorf, Department for Diagnostic and Interventional Radiology and Nuclear Medicine, Hamburg, Germany
,
I Apostolova
1   University Medical Center Hamburg-Eppendorf, Department for Diagnostic and Interventional Radiology and Nuclear Medicine, Hamburg, Germany
,
S Klutmann
1   University Medical Center Hamburg-Eppendorf, Department for Diagnostic and Interventional Radiology and Nuclear Medicine, Hamburg, Germany
,
J Csirik
3   University of Szeged, Department of Computer Science, Szeged, Hungary
,
J Mester
1   University Medical Center Hamburg-Eppendorf, Department for Diagnostic and Interventional Radiology and Nuclear Medicine, Hamburg, Germany
,
R Buchert
1   University Medical Center Hamburg-Eppendorf, Department for Diagnostic and Interventional Radiology and Nuclear Medicine, Hamburg, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2019 (online)

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    Ziel/Aim:

    There is a tradeoff between count sensitivity (-> statistical noise) and spatial resolution (-> contrast recovery) in conventional SPECT associated with the use of parallel-hole or fan-beam collimators for photon collimation. Multi-pinhole (MPH) technology, successful in small animal SPECT, has potential for concurrent improvement of count sensitivity and contrast recovery also in clinical SPECT of 'small' organs. This study evaluated a MPH collimator specifically designed for dopamine transporter (DAT) SPECT.

    Methodik/Methods:

    The 3-dimensional count sensitivity profile of a triple head SPECT system (Mediso AnyScan® TRIO) with the MPH collimators was measured with a Tc-99 m point source placed on the lattice points of a 1 cm grid covering the whole field-of-view (FOV). Measurements of an anthropomorphic striatum phantom were performed with varying striatum-to-background activity concentration ratio. MPH projection data were reconstructed using the iterative reconstruction algorithm (TeraTomo™) of the SPECT system software with default parameter settings for patient scans. Recovery of the striatum-to-background (S/B) contrast was assessed by the contrast recovery coefficient (CRC =(measured S/B – 1)/(true S/B – 1)). Count sensitivity and phantom measurements were also performed with a 2-head SPECT system with fan-beam collimators (OSEM reconstruction with ENC-DAT settings).

    Ergebnisse/Results:

    Total sensitivity in the center of the FOV was 592 cps/MBq for the 3-head MPH system compared to 225 cps/MBq for the 2-head fan-beam system. Sensitivity of the MPH system decreased towards the edges of the FOV. The full width of the sensitivity profile at 200 cps/MBq was 21 cm (transaxial) and 11 cm (axial). Contrast recovery in putamen/caudate was 0.78/0.66 with MPH SPECT and 0.55/0.45 with fan-beam SPECT.

    Schlussfolgerungen/Conclusions:

    MPH SPECT provides considerable improvement of DAT SPECT with respect to count sensitivity and striatum-to-background contrast recovery.


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