Nuklearmedizin 2019; 58(02): 176-177
DOI: 10.1055/s-0039-1683687
Poster
Leuchtfeuer
Georg Thieme Verlag KG Stuttgart · New York

Simultaneous Recordings of Gadolinium-based MRI Contrast Agent and PET Tracer Arterial Input Function in Mice Using an Extracorporeal Shunt

P Backhaus
1   Uniklinik Münster, Klinik für Nuklearmedizin, Münster
,
F Büther
1   Uniklinik Münster, Klinik für Nuklearmedizin, Münster
,
L Wachsmuth
2   Universität Münster, Translational Research Imaging Center – TRIC, Münster
,
L Frohwein
3   Universität Münster, European Institute for Molecular Imaging – EIMI, Münster
,
KP Schäfers
3   Universität Münster, European Institute for Molecular Imaging – EIMI, Münster
,
S Hermann
3   Universität Münster, European Institute for Molecular Imaging – EIMI, Münster
,
C Faber
2   Universität Münster, Translational Research Imaging Center – TRIC, Münster
,
M Schäfers
1   Uniklinik Münster, Klinik für Nuklearmedizin, Münster
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2019 (online)

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    Ziel/Aim:

    In small animals quantification of the dynamic arterial input function (AIF) is equally challenging for PET and MRI. AIF measurements provide the basis for kinetic modeling of both MR contrast agents (CA) and PET tracers.

    Methodik/Methods:

    Intracranial tumor-bearing mice received an extracorporeal shunt from the femoral artery to the tail vein. MRI scanning was performed using a 9.4 T MRI (Bruker BioSpec) and a cryo-cooled surface coil. The extracorporeal line featured two thickenings which resided in the MRI field of view. A MRI-compatible measuring chamber for a beta-Microprobe (biospace lab) was included in the circulation. Dynamic MRI scanning of the head was performed for 15 minutes using a 3D FLASH with a spatial resolution of 0.175 × 0.175 × 1 mm and a temporal resolution of 4.015 s. A 100 µl solution containing 10 – 20 MBq F-18-PSMA-1007 and CA (Gadovist, 35 mM) was injected intravenously at 1 ml/min. Dispersion correction for MR CA was performed based on the recorded distinct dispersion effect at the two interspaced thickenings. Dispersion correction for the PET tracer was performed empirically based on calibration measurements.

    Ergebnisse/Results:

    Our method allows for simultaneously resolving the AIF of MR CA and PET radiotracer as well as CA dynamics in tissue. The MR-based quantification shows good agreement with circulated human blood with defined CA concentrations in the range of expected concentrations and flow velocities. The CA-AIFs of 8 recorded mice show a close range of peak concentrations, little noise and a typical AIF curve shape related to the simultaneously recorded PET-tracer AIFs.

    Schlussfolgerungen/Conclusions:

    We present the first dual recordings of AIFs of a MR CA and a PET tracer in mice. This supports evaluation approaches to deduce the CA/PET tracer AIF form one another. Further, it might provide the basis for simultaneous and integrated modeling of PET tracer and CA kinetics in mice.


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