Proteome analysis of the perilymph: Identification of biomarkers

Introduction:

The success that can be achieved with a cochlear implant depends on many factors. Unfortunately, there are currently only a few parameters that allow an assessment of speech understanding with an implant. The aim of the study is to show a possible correlation between the proteome of the perilymph and speech understanding with the cochlear implant.

Methods:

Patients receiving a cochlear implant with defined otologic disease were included in this study. Before the insertion of the electrodes, the recovery of perilymph for the determination of proteins is done by mass spectrometry. These laboratory results are correlated with the patients' language test results 1 year.

Before the insertion of the electrodes, the recovery of perilymph for the determination of proteins is done by mass spectrometry.

Results:

It can be stated that the production of perilymph is sufficient for a reliable laboratory analysis. The first results show that the specific protein composition of the perilymph is representable. Whether these can be clearly assigned to a defined basic otological disease or to the outcome will be shown in further analyzes.

Conclusions:

We assume that bioinformatic analysis of a high number of samples will allow the validation of certain proteome profiles of the perilymph as a conceivable predictive factor in cochlear implantation. Whether we can prove this definitively in this small group of patients is rather questionable. Of particular importance is this laboratory-chemical based and therefore objective prediction, especially in the large group of patients who are rest hearing.

Caroline Krüger

Medizinische Hochschule Hannover,

Carl-Neuberg-Str.1, 30625

Hannover

Email: [e-mail]

Publication History

Publication Date:
23 April 2019 (online)