Four new benzoyltyramines from the peels of Atalantia monophylla and their cytotoxicity

Four new benzoyltyramines, atalantums H-K (1-4)^[ [ ¹ ] ^], and seven known compounds (5-11)^[ [ ² ] ^] were isolated from the peels of Atalantia monophylla. All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC₅₀ values ranging from 16-25 µg/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC₅₀ values ranging from 15-18 µg/mL and an IC₅₀ value of 80.2 µg/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents.

Fig. 1

• References

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