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DOI: 10.1055/s-0039-3399885
Four new benzoyltyramines from the peels of Atalantia monophylla and their cytotoxicity
Publication History
Publication Date:
20 December 2019 (online)
Four new benzoyltyramines, atalantums H-K (1-4)[ [ 1 ] ], and seven known compounds (5-11)[ [ 2 ] ] were isolated from the peels of Atalantia monophylla. All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC50 values ranging from 16-25 µg/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC50 values ranging from 15-18 µg/mL and an IC50 value of 80.2 µg/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents.
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References
- 1 Sombatsri A, Thummanant Y, Sribuhom T, Wongphakham ST, Yenjai C. Atalantums H-K from the peels of Atalantia monophylla and their cytotoxicity. Nat Prod Res 2018; DOI: DOI: 10.1080/14786419.2019.1576042.
- 2 Sribuhom T, Boueroy P, Hahnvajanawong C, Phatchana R, Yenjai C. Benzoyltyramine alkaloids atalantums A-G from the peels of Atalantia monophylla and their cytotoxicity against cholangiocarcinoma cell lines. J Nat Prod 2017; 80: 403-408
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References
- 1 Sombatsri A, Thummanant Y, Sribuhom T, Wongphakham ST, Yenjai C. Atalantums H-K from the peels of Atalantia monophylla and their cytotoxicity. Nat Prod Res 2018; DOI: DOI: 10.1080/14786419.2019.1576042.
- 2 Sribuhom T, Boueroy P, Hahnvajanawong C, Phatchana R, Yenjai C. Benzoyltyramine alkaloids atalantums A-G from the peels of Atalantia monophylla and their cytotoxicity against cholangiocarcinoma cell lines. J Nat Prod 2017; 80: 403-408
![](https://www.thieme-connect.de/media/plantamedica/201918/thumbnails/10.1055s-0039-3399885-f0001.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)