Endoscopic Surgery for Chondrosarcoma of the Nasal Cavity and Sinus

Objective: To investigate the surgical treatment of chorndrosarcoma of the nasal cavity and sinus under nasal endoscope, and to summarize the clinical manifestations, diagnosis, treatment, and prognosis of this disease.

Methods: the clinical data of seven patients with chorndrosarcoma of the nasal cavity and sinus treated with nasal endoscopic surgery were retrospectively analyzed, and the surgical techniques and clinical characteristics of chondrosarcoma of the nasal cavity and sinus were summarized.

Results: Seven patients underwent nasal endoscopic resection, and the follow-up effect was good. The clinical features of chondrosarcoma of the nasal cavity and sinus are complex and varied, and it is difficult to make a definite diagnosis. Early chondrosarcoma of the nasal cavity and sinus is limited to the nasal sinus, the operation is easier, the treatment effect is better. The advanced lesions are extensive and even easy to involve the orbital and skull base. The operation is difficult and risky, and the prognosis is poor. Irregular plaque calcification is a typical imaging feature of this disease.

Table 1 Clinical data of seven patients

	Sex	Age (y)	Primary site of tumor	Main symptoms	Pathology and S-100	Follow-up
1	F	28	Posterior septum involving sphenoid sinus	bilateral nasal obstruction for 3 months	Chondrosarcoma, ? level, (+)	4 years without recurrence
2	F	56	The posterior septum involves the base of the skull	Blurred vision in the right eye with diplopia for 20 days	Chondrosarcoma, ? level, (+)	No recurrence in 2 years
3	F	77	The maxillary sinus involves the bas of the skull	Left nasal congestion for 5.5 years left eye vision loss for 20 days	Chondroma with a tendency to malignancy	4 years of progression
4	F	81	The posterior septum involves the base of the skull	Left nasal obstruction for 1 year left nasal bleeding for 4 days	Chondrosarcoma, ? level, (+)	No recurrence in 1 year
5	M	34	Maxillary sinus	Left nasal congestion for 5 months	Chondrosarcoma, ? level, (+)	No recurrence in 1 year
6	M	56	The maxillary sinus involves the base of the skull	Repeated right nasal bleeding for 2 months	Chondrosarcoma, ? level, (+)	No recurrence in 2 years
7	F	40	The maxillary sinus involves the base of the skull	Repeated right nasal bleeding for 2 months	Chondrosarcoma,? level, (+)	No recurrence in 3 years

Conclusion: Endoscopic radical resection is the first choice for the treatment of chondrosarcoma of the nasal cavity and sinus. Early diagnosis of chondrosarcoma of the nasal cavity and sinus is difficult, which should be combined with CT, MR imaging, and histopathology.

No conflict of interest has been declared by the author(s).