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DOI: 10.1055/s-0040-1704064
COMPLEX ANTITHROMBOTIC THERAPY IN PATIENTS WITH ACUTE LOWER GASTROINTESTINAL BLEEDING: CLINICAL OUTCOMES
Publication History
Publication Date:
23 April 2020 (online)
Aims Analyze the relationship of CAT (dual treatment: antiplatelet-anticoagulant or antiplatelet-antiplatelet) and the adverse outcomes in patients with acute lower gastrointestinal bleeding (LGB).
Methods International Classification of Diseases, 9th Revision, Clinical Modification codes for admission diagnosis were used to identify retrospectively a cohort of patients with LGB from January 2013 to December 2017 hospitalized in a tertiary care, university-affiliated hospital. The outcomes studied were: A) severe LGB, B) Re-bleeding, C) Transfusion requirements, D) Treatment (endoscopy, interventional radiology or surgery), E) Readmission and F) Death. For discrete variables we tested for significant differences between groups with X2 tests If ≥25 % of cells had expected values less than 5; Fisher exact test was used. P values < 0.05 were considered statistically significant. Differences in outcomes were expressed in odds ratio (OR) with 95% confidence intervals (95%CI).
Results Were identified 417 patients (88.5%) in not CAT group versus 54 (11.5%) in CAT group. Mean age was 76.8 years in CAT group versus 72.6 in not CAT group, 203 (48.7%) were men in not CAT group and 42 (77.8%) in patients using CAT. The most common source bleeding was diverticular 114 (27.3%) in not CAT group and ischemic colitis 13 (24.1%) in CAT group. Outcomes of patients are show in [Table 1.]
Conclusions Patients in CAT have a higher frequency of severe LGB; transfusion and readmission compared to patients without CAT. No difference was found between them for re-bleeding, need for treatment and death.
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