OVERSTITCH SX ENDOSCOPIC SUTURING SYSTEM FOR GASTROINTESTINAL APPLICATIONS: A MULTICENTER EUROPEAN REGISTRY

Aims The aim of this registry is to collect demographic, procedural characteristics and follow-up (FU) outcomes of endoscopic suturing from multiple european centers using OverStitch Sx.

Methods A retrospective analysis of a prospectively collected series of any patient who underwent an endoscopic suturing procedure using the OverStitch Sx for a gastrointestinal application from January 2018 to November 2019 was performed.

This registry includes five main groups: Closure of full thickness defects, closure of mucosal defects, Fixation of endoprosthetics, GI Bleeding, Other.

Results To date 107 patients have been entered into the registry. 9 European centers contributed to this first collection with a varying number of procedures from each center (max: 43; min: 1).

There were no cases of failure to introduce the device to the target area. Furthemore, suturing was technically achieved as intended in 106 cases. The total clinical success rate was 85,9%.

In the group of closure of mucosal defects, FU has been reported for 10 patients (range: 90 days-1 year) with a 100% success rate. Patients who underwent fistula closure had a follow-up range of 30 to >90 days with a clinical success rate of 61,5%. All cases of perforation were successfully closed initially with a continued success rate of 94.4%. Closure of post-op leaks was performed in 7 patients with a clinical success rate of 80 %. 30 stents (located in the esophagus: 20; stomach: 5 and duodenum: 5) were fixed by suturing with a continued success-rate in patients with reported FU ranging from 30 to 90 days of 86,6 %. Other procedures included all bariatric revision procedures. FU has been reported for 3 patients with a 100% success rate.

Conclusions This data demonstrates safety and feasibility of endoscopic suturing for several GI indications. This European registry is a valuable tool to pool outcomes and to address future research directions.