REAL-WORLD PATIENT EXPERIENCE WITH 1L NER1006 AS A BOWEL PREPARATION FOR COLONOSCOPY: A PROSPECTIVE, MULTI-CENTRE SURVEY COVERING 707 HEALTH CARE PROVIDERS IN THE UNITED STATES

Aims A survey assessed real-world patient experience and treatment satisfaction in US adults who received 1L polyethylene glycol (PEG) NER1006 (PLENVU).

Methods Patients from US community gastroenterology practices completed an online survey within 2 weeks post-colonoscopy. Questions covered patient history of colonoscopy and prior bowel preparation(s) prescribed, experience during administration of PLENVU, and patient satisfaction with the bowel preparation process. Nine-point grading scales captured the ease of preparation and consumption; importance of volume requirement; and patient satisfaction. Results are presented descriptively.

Results Among 1630 enrolled patients from 707 health care providers, 1606 underwent colonoscopy (male/female/NA 34.9%/62.5%/2.6%, mean age 54.4 years). 74.7% patients had no family history of colon cancer, 62.6% had previous colonoscopy, and 64.8% were having a screening colonoscopy. Among 1598 patients who completed the survey Sept-2018 to Feb-2019, 91.6% took PLENVU as overnight split dosing and 8.4% in morning of colonoscopy. Nearly all (97.6%) consumed all or most of their treatment ([Table]). The low total required ingestion volume of PLENVU was at least medium important for 93.2% patients. Among the 1005 patients with previous bowel prep experience 89.5% were at least moderately and 62.5% were very satisfied with PLENVU overall. Most, 65.3%, stated a much better or better experience with PLENVU versus bowel preps they had previously used.

Tab. 1 Selected topics with response categories

	Patients, n (%); n = 1598
Volume of bowel preparation regimen completed All; Most; At least half; Less than half	1392 (87.1); 167 (10.5); 29 (1.8); 10 (0.6)
“How important is it to you that using PLENVU required only 64 US fl oz of total solutions?” Very important (score, 7-9); Medium important (score, 4-6); Not important (score, 1-3);	1206 (75.5); 283 (17.7); 109 (6.8)
“How was your experience with PLENVU compared to the other bowel cleansing medications(s) you previously used?” Much better/better (score, 7-9); About the same (score, 4-6); Worse/much worse (score, 1-3);	656 (65.3); 195 (19.4); 154 (15.3); n = 1005
“How satisfied were you with PLENVU, overall?” Not satisfied (score, 1-3); Okay (score, 4-6); Very satisfied (score, 7-9);	161 (10); 433 (27); 1004 (63)

Conclusions This first real world patient experience survey for PLENVU showed that patient experience with PLENVU was favourable and adherence was high. The majority of patients were very/moderately satisfied with the overall experience and found it much better/better than other bowel preparations used.