Endoscopy 2020; 52(S 01): S273
DOI: 10.1055/s-0040-1704861
ESGE Days 2020 ePoster presentations
Thursday, April 23, 2020 09:00 – 17:00 Stomach and small intestine ePoster area
© Georg Thieme Verlag KG Stuttgart · New York

GENOTYPING OF HELICOBACTER PYLORI CAGA EPIYA MOTIF AS A RISK FACTOR OF GASTRIC LESIONS SEVERITY IN A MOROCCAN POPULATION

M Reda Jouimyi
1   Pasteur Institute of Morocco, Laboratory of Helicobacter pylori and Gastric Pathologies, Casablanca, Morocco
2   Faculty of Sciences Ben M’sik, University Hassan II, Laboratory of Biology and Health, Casablanca, Morocco
,
G Bounder
1   Pasteur Institute of Morocco, Laboratory of Helicobacter pylori and Gastric Pathologies, Casablanca, Morocco
2   Faculty of Sciences Ben M’sik, University Hassan II, Laboratory of Biology and Health, Casablanca, Morocco
,
H Boura
1   Pasteur Institute of Morocco, Laboratory of Helicobacter pylori and Gastric Pathologies, Casablanca, Morocco
,
I Essaidi
1   Pasteur Institute of Morocco, Laboratory of Helicobacter pylori and Gastric Pathologies, Casablanca, Morocco
3   Faculty of Medicine and Pharmacy University Hassan II, Microbiology Department, Casablanca, Morocco
,
W Badre
4   Ibn Rochd University Hospital Center, Gastroenterology Department, Casablanca, Morocco
,
M Eljihad
4   Ibn Rochd University Hospital Center, Gastroenterology Department, Casablanca, Morocco
,
M Kadi
4   Ibn Rochd University Hospital Center, Gastroenterology Department, Casablanca, Morocco
,
A Bendahmane
5   National Social Security Fund, Gastroenterology Department, Casablanca, Morocco
,
H Benomar
6   Pasteur Institute of Morocco, Laboratory of Histo-Cytopathology, Casablanca, Morocco
,
K Zerouali
3   Faculty of Medicine and Pharmacy University Hassan II, Microbiology Department, Casablanca, Morocco
,
H Lebrazi
2   Faculty of Sciences Ben M’sik, University Hassan II, Laboratory of Biology and Health, Casablanca, Morocco
,
A Kettani
2   Faculty of Sciences Ben M’sik, University Hassan II, Laboratory of Biology and Health, Casablanca, Morocco
,
F Maachi
1   Pasteur Institute of Morocco, Laboratory of Helicobacter pylori and Gastric Pathologies, Casablanca, Morocco
› Author Affiliations
Further Information

Publication History

Publication Date:
23 April 2020 (online)

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    Aims Helicobacter pylori (H. pylori) persistent infection lead to atrophic gastritis (AG) and intestinal metaplasia (IM) that can lead to gastric cancer (GC). The severity of the gastric lesions is related to genetic variability of H. pylori virulence factors. The cagA gene is one of the most studied virulence factors of H. pylori and its oncogenic potential is linked to its high polymorphic EPIYA motifs. The aim of this study was to evaluate the association of EPIYA motifs with the risk of AG and IM in a Moroccan population.

    Methods A total of 210 patients suffering from gastric lesions (chronic gastritis, AG, and IM) was enrolled. H. pylori infection and the type of lesions were diagnosed by ureC PCR and histological examination, respectively. Detection of the cagA gene, as well as genotyping of EPIYA motifs were carried out by PCR.

    Results The prevalence of H. pylori and cagA gene was 95% and 37%, respectively. CagA-positive strains were more associated with the risk of IM than AG. The EPIYA motifs detected were: EPIYA-ABC (58%), EPIYA-ABCC (22%), EPIYA-AB (20%). The EPIYA-ABCC motif increases the risk of IM (OR = 23, 95%CI = 1.99–273.29, p-value = 0.007), compared to AG (CI = 7, 95%CI = 0.56–86.32, p-value = 0.28).

    Conclusions The EPIYA-ABCC motif might be a useful marker for the identification of patients at high risk of developing IM that can lead to GC.


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