CC BY-NC-ND 4.0 · Laryngorhinootologie 2020; 99(S 02): S154
DOI: 10.1055/s-0040-1710997
Abstracts
Oncology

Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC

K Sharaf
1   HNO-Klinik des Klinikums der Universität München München
,
J Kitz
2   Institut für Pathologie der Universitätsmedizin Göttingen Göttingen
,
M Canis
1   HNO-Klinik des Klinikums der Universität München München
,
M Jakob
1   HNO-Klinik des Klinikums der Universität München München
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    Introduction Cancer stem cells (CSCs) are hold accountable for the progress of head and neck squamous cell carcinoma (HNSCC). In the presented study, we evaluated the prognostic value of CSC markers in two particular HNSCC cohorts.

    Methods This two cohort study consisted of 85 patients with advanced stage HNSCC, treated with primary radio(chemo)therapy (pRCT), and 95 patients with HNSCC, treated with surgery and partially adjuvant radio(chemo)therapy. Overall survival (OS), disease free survival (DFS), and disease specific survival (DSS) were assessed. Samples were assessed for the expression of different molecular stem cell markers (ALDH1, BCL11B, BMI-1, and CD44).

    Conclusions In the pRCT cohort, none of the baseline patient and tumor features exhibited a statistically significant relation with survival in both the cohort and HPV-stratified subcohorts. High expression of BMI-1 significantly decreased OS and DFS, while high expression of CD44 decreased all modes of survival. In the surgical cohort, classical prognosticators such as HPV status, R1 resection, and nodal status in HPV negative HNSCC played a significant role but the tested CSC markers showed no significant influences on prognosis.

    Conclusion In patients with advanced or late stage HNSCC, testing for CSC markers and early use of targeted therapies might be beneficial, especially if many comorbidities exist or disease is inoperable.

    Poster-PDF A-1161.PDF


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    Dr. med. Kariem Sharaf
    HNO-Klinik des Klinikums der Universität München
    Marchioninistraße 15
    81377 München

    Publication History

    Article published online:
    10 June 2020

    © 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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