Endoscopy 2021; 53(S 01): S98-S99
DOI: 10.1055/s-0041-1724507
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Efficacy and Safety of Very Low-Volume Bowel Preparation With 1L Plenvu Comparison With 2L Peg-Asc: Multicenter, Randomized, Endoscopist-Blinded Study

SN Hong
1   Samsung Medical Center, Department of Medicine, Seoul, Korea, Republic of
,
Lee CK
2   Kyung Hee University School of Medicine, Center for Crohn’s and Colitis, Department of Gastroenterology and Hepatology, Seoul, Korea, Republic of
,
J PIm
3   Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of
,
Choi CH
4   Chung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea, Republic of
,
Byeon JS
5   Asan Medical Center, University of Ulsan College of Medicine, Department of Gastroenterology, Seoul, Korea, Republic of
,
Cho YS
6   Seoul St. Mary’s Hospital, The Catholic University of Korea, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
Jung SA
7   Ewha Womans University College of Medicine, Department of Internal Medicine, Seoul, Korea, Republic of
,
Kim TI
8   Yonsei University College of Medicine, Department of Internal Medicine, Seoul, Korea, Republic of
,
Jeen YT
9   Korea University Anam Hospital, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
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    Aims Polyethyleneglycol (PEG)-based bowel preparation is effective and safe but required high volume intake, which reduces adherence and tolerability. Although 2L PEG-Asc enables small volume preparation, lower-volume bowel preparation is beneficial for patients.

    Methods This multicenter, randomized, endoscopist-blinded study has randomized the patients requiring colonoscopy to receive 1L PEG-Asc, Plenvu versus 2L PEG-Asc at nine hospitals in Korea. Bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS). The primary endpoints were overall bowel cleansing success (each BBPS segment score ≥2).

    Results Of 360 patients, bowel cleansing was analyzed in 346 (1L PEG-Asc, n = 174; 2L PEG-Asc, n = 172). 1L PEG-Asc showed non-inferiority in successful bowel cleansing compared with 2L PEG-Asc (93.10 % [162/174] vs. 91.86 % [158/172], difference,1.24 %; one-sided 97.5 % lower confidence limit, -4.31 %; non-inferiority p <0.0001). Right colon BBPS score was significantly higher in 1L PEG-Asc than 2L PEG-Asc group (2.56±0.60 vs. 2.43±0.60, p = 0.029), although the differences of transverse and left colon BBPS scores were not significant between the groups. Polyp detection rate (PDR) of 1L PEG-Asc group was significantly higher than that of 2L PEG-Asc group (48.85 % vs. 37.79 %, p = 0.0379) and adenoma detection rate (ADR) of 1L PEG-Asc group was numerically higher than that of 2L PEG-Asc group (24.71 % vs. 20.35 %, p = 0.3314). The mean numbers of polyps and adenomas per patient of 1L PEG-Asc group were tended to be higher than those of 2L PEG-Asc group (0.33 ± 0.49 vs. 0.27 ± 0.48, p = 0.0606; 0.14 ±0.31 vs. 0.12 ± 0.31, p = 0.3427). 1L PEG-Asc was well tolerated, with more mild adverse events compared with 2L PEG-Asc (65.71 % [115/175] vs. 52.91 % [91/172], p = 0.0152).

    Conclusions Plenvu was as effective in overall bowel cleansing as 2L PEG-Asc, with improved right colon cleansing and PDR.

    Citation: Hong SN, Lee CK, PIm J et al. eP6 EFFICACY AND SAFETY OF VERY LOW-VOLUME BOWEL PREPARATION WITH 1L PLENVU COMPARISON WITH 2L PEG-ASC: MULTICENTER, RANDOMIZED, ENDOSCOPIST-BLINDED STUDY. Endoscopy 2021; 53: S98.


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    Publication History

    Article published online:
    19 March 2021

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