Eosinophilic Gastrointestinal Disorders: Endoscopic Features and Treatment

Aims Eosinophilic digestive disorders (EGD) are a rare condition characterized by extensive eosinophilic infiltration of a segment of the digestive tract.The goal of our work is to study the clinical, endoscopic and therapeutic characteristics of EGD.

Methods This is a retrospective, descriptive study during 9 years (2010-2019) including all the patients treated in our department for an EGD .The diagnosis was established by the presence of eosinophilic infiltration of the digestive wall on the biopsies and after exclusion of any parasitic cause or extra digestive disease. Eosinophilic esophagitis was not included in this report.

Results Fifteen cases were collected,10 women and 5 men.The average age was 43 years [12–74 years].Our study included 5 cases of eosinophilic gastritis (EG),2 cases of eosinophilic gastroenteritis (EGE) and 8 cases of eosinophilic colitis (EC).Associated atopy was found in 5 patients.Revealing symptoms were chronic diarrhea in 7 cases, abdominal pain in 6 cases, vomiting in 2 cases and ascites in 2 cases.Blood hypereosinophilia was noted in 6 patients (40 %).An immunoglobulin E (IgE) test was performed in 10 patients and showed a high level in four cases.For EG and EGE, upper gastrointestinal endoscopy showed nodular gastric mucosa in 3 cases, erosive gastric lesions in 2 cases, congestive gastric mucosa in 2 cases and nodular duodenal mucosa in 1 case.For EC, ileocoloscopy was normal in the majority of cases (n = 6) and showed superficial colonic ulcerations in 2 cases.The treatment recommended in our patients was based on transit retarders in 2 cases, salicylates in 6 cases and systemic corticosteroid therapy in 5 cases.The evolution was favorable in the majority of cases.A single patient, with EGE, presented with a relapse following stopping corticosteroids and requiring the use of thiopurines.

Conclusions EGD remains a rare disease although its frequency is increasing over the years. Unexplained digestive symptomatology must suggest this diagnosis.

Citation: Bradai S, Mahmoudi M, Khsiba A et al. eP161 EOSINOPHILIC GASTROINTESTINAL DISORDERS: ENDOSCOPIC FEATURES AND TREATMENT. Endoscopy 2021; 53: S148.

Publication History

Article published online:
19 March 2021