Virtual Chromoendoscopy for Real-Time Assessment of Colorectal Polyps’ Histology: Is There any Predictor of Diagnostic Performance?

Aims Virtual chromoendoscopy (VC) such as Narrow band imaging (NBI) or Flexible spectral imaging color enhancement (FICE) offer better resolution of the pit pattern and the vascular pattern of colorectal polyps, which allows real-time assessment of these lesions’ histology. The aim of this study was to assess virtual chromoendosctopy’s performance in predicting colorectal polyps’ histology and to determine predictors of diagnostic accuracy.

Methods A prospective study from April 2018 to February 2020 including patients who underwent colonoscopy and had one or more polyps being characterized by VC was conducted (FICE or NBI). All included polyps were completely removed for histopathological analysis.

The evaluation of VC performance in distinguishing neoplastic lesions from non-neoplastic ones was made by analyzing the Reveiver operating Characteristics (ROC) curve with measurement of the area under the curve (AUC) and by calculating sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy. Fisher Test was used for determination of predictors of diagnostic accuracy (qualitative variables).

Results Sixty-four polyps with a mean size of eight [2 – 30] were included in our study, 25 of which were non-neoplastic versus 39 neoplastic polyps. Se, Sp, PPV, NPV, AUC and diagnostic accuracy were respectively 94.9 %, 92 %, 94.9 %, 92 %, 0.934 and 94 %. Comparing both technologies used (FICE versus NBI), there was no significant difference in terms of diagnostic accuracy (p=1.000). In addition, neither the polyp size (p=0.619), neither the polyp morphology (p=1.000), nor the polyp location (p=1.000) was associated with the diagnostic accuracy.

Conclusions Our study proved that FICE and NBI can provide an accurate and precise instantaneous assessment of colorectal polyps’ histology with a comparable diagnostic performance and regardless of the polyp’s characteristics.

Citation: Ferchichi I, Sabbah M, Bellil N et al. eP178 VIRTUAL CHROMOENDOSCOPY FOR REAL-TIME ASSESSMENT OF COLORECTAL POLYPS’ HISTOLOGY: IS THERE ANY PREDICTOR OF DIAGNOSTIC PERFORMANCE?. Endoscopy 2021; 53: S155.

Publication History

Article published online:
19 March 2021