Study of Diagnostic Accuracy of Fecal Immunochemical Test for Colorectal Cancer Screening

Aims To study the diagnostic accuracy of Fecal Immunochemical Tests for Colorectal Cancer screening in Myanmar people

Methods It was a cross-sectional descriptive study. 305 healthy volunteers who fulfilled the selection criteria were enrolled and the study was performed at Mandalay General Hospital, Myanmar from January 2018 to June 2019. Qualitative FIT was tested for one time. Colonoscopy was done to all cases on the scheduled date .Data were entered into Microsoft Office Excel 2007 software and data analysis was done by Stata13 software.

Results

Tab. 1

FIT	Colonic adenoma	Normal
Positive	23 %	29 %
Negative	18 %	37 %

Mean age of participants was 53.8 year. Most common age group was between 50 and 59 year. 75 % of cases were female. FIT was positive in 117 cases and negative in 188 participants. The test positivity rate was 38.36 %. FIT had sensitivity 43.5 %, specificity 63 %, positive predictive value 23.1 % and negative predictive value 81.4 % in this study.There was no colorectal cancer in the study. Colonic adenomas were detected in 62 cases. Colorectal adenoma detection rate in FIT positive subjects was 23 % and it was only 18 % in FIT negative cases (p-0.34). The area under the curve of FIT for colorectal adenoma was 0.53.

Conclusions The diagnostic accuracy of FIT was not good in this study. FIT positivity was associated with increased risk of colorectal adenoma. To use in screening program, FIT should be tested 2 or more times with ensuring to protect environmental effect especially in hot weather.

Citation: Lin SS ¹, Ni N¹, Aung MM et al. eP250 STUDY OF DIAGNOSTIC ACCURACY OF FECAL IMMUNOCHEMICAL TEST FOR COLORECTAL CANCER SCREENING. Endoscopy 2021; 53: S180.

Publication History

Article published online:
19 March 2021