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DOI: 10.1055/s-0041-1724782
Adequate and High-Quality Cleansing Success From Under 5 to at Least 13 Hours After Bowel Preparation Start With Same Day 1L Ner1006: Post Hoc Analysis
Aims Urgent colonoscopies within 8 hours of presentation may increase the diagnostic yield1. Bowel preparations with sustained cleansing efficacy may help endoscopists examine more patients per day. We analysed if 1L polyethylene glycol (PEG) NER1006 could rapidly attain high-quality colon cleansing success and sustain it over a period of typical daily working hours.
Methods Analysis of 262 patients using same-day morning-only dosing with NER1006 in the randomized clinical trial MORA2. Included adult patients had their colonoscopy within 13 hours from the start of the bowel preparation and overall cleansing quality assessed by site endoscopists using the validated Harefield Cleansing Scale (HCS). Success rates were calculated for overall adequate (HCS AB) and high-quality (HCS A; all segments stool free) cleansing. Patient quartiles (Q1-Q4) with similar samples sizes but differing time lapses from the start of the bowel preparation to the start of the colonoscopy were compared versus Q1 using a 2-sided t-test.
Results Time lapses ranged from 4.67 to 12.97 hours ([Table]). Patients with the shortest and the longest time lapses attained both adequate and high-quality cleansing success. Adequate cleansing success was comparable across quartiles Q1 (87.9 % (58/66)), Q2 (89.6 % (60/67); P = 0.762), Q3 (92.3 % (60/65); P = 0.400) and Q4 (95.3 % (61/64); P = 0.130). Substantial high-quality cleansing success was also attained in all quartiles, with similar rates across quartiles Q1 (69.7 % (46/66)), Q2 (67.2 % (45/67); P = 0.756) and Q3 (66.2 % (43/65); P = 0.667). A numerically lower rate was observed in Q4 (56.3 % (36/64); P = 0.114).
Conclusions Same-day morning-only dosing with NER1006 attained successful adequate and high-quality cleansing within 5 hours and up to at least 13 hours from the start of bowel preparation. These findings encourage further research into the diagnostic benefits of urgent colonoscopies and endoscopists to consider increasing their daily colonoscopy capacity.
Citation:Álvarez-González MA, Halonen J. eP288 ADEQUATE AND HIGH-QUALITY CLEANSING SUCCESS FROM UNDER 5 TO AT LEAST 13 HOURS AFTER BOWEL PREPARATION START WITH SAME DAY 1L NER1006: POST HOC ANALYSIS. Endoscopy 2021; 53: S192.
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References
- 1 Gastroenterol Am J.. 2005; ; 100 (11) 2395-2402.
- 2 Endoscopy. 2019; Jan; 51 (01) 60-72.
Publication History
Article published online:
19 March 2021
© 2021. European Society of Gastrointestinal Endoscopy. All rights reserved.
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References
- 1 Gastroenterol Am J.. 2005; ; 100 (11) 2395-2402.
- 2 Endoscopy. 2019; Jan; 51 (01) 60-72.