Predictors Of Gastrointestinal Transit Times In Colon Capsule Endoscopy

Aims To obtain images of the entire gastrointestinal tract by Colon Capsule Endoscopy (CCE), transit times have to be fast enough to achieve completion while not missing any lesions. We aimed to identify predictors for CCE transit times in a population-based cohort.

Methods Participants received CCE with corresponding bowel preparation (2L polyethylene glycol and 2L water, split-dose) and booster regimen (10mg metoclopramide (if capsule remained in stomach > 1 hour) and 0.5L oral sulfate solution (OSS) split dose). The following predictors were assessed: age, gender, body mass index (BMI), smoking, coffee and fiber intake, physical activity, changed stool pattern, history of abdominal surgery, medication use and CCE findings. Multivariable logistic and linear regressions with backward elimination were performed to predict CCE completion rate and transit times.

Results 451 CCE procedures were analyzed. Completion rate was 51.9 %. Participants with a lower BMI had a slower stomach, small bowel (SB) and total transit (β=0.104, p = 0.014; β=0.137, p = 0.001; β=0.120, p = 0.013). Other predictors for slower SB transit were unchanged stool pattern (β=0.084, p = 0.049) and no need to use the prescribed metoclopramide (β=0.140, p = 0.001). Participants with higher fiber intake had a slower colonic transit (β=0.111, p = 0.025). Completion rate was higher among older participants (OR 1.539, 95 % CI 1.040-2.278, p = 0.031) and among those with changes in stool pattern (OR 2.273, 95 % CI 1.202-4.297, p = 0.012), while those with history of abdominal surgery (OR 0.536, 95 % CI 0.358-0.804, p = 0.003) had a lower completion rate.

Conclusions Lower BMI, unchanged stool pattern, fiber intake, younger age and history of abdominal surgery resulted in slower CCE transit times or lower completion rate. In future practice these factors can be considered to intensify the preparation protocol. The faster SB transit in participants who took metoclopramide due to a long stomach transit suggests that it might be beneficial to use metoclopramide in all CCE procedures.

Citation Moen S, Vuik FER, Voortman T et al. eP466 PREDICTORS OF GASTROINTESTINAL TRANSIT TIMES IN COLON CAPSULE ENDOSCOPY. Endoscopy 2021; 53: S250.

Publication History

Article published online:
19 March 2021