ASSESSMENT OF RISK VARIABLES AND MORBIDITY IN PATIENTS WITH CIRRHOTIC WITH ASSOCIATED PORTAL VEIN THROMBOSIS IN A SINGLE ASIAN CENTRE -A OBSERVATIONAL STUDY

Aims To Study was done to determine the various risk factors and prognostic factors of newly detected portal vein Thrombosis(PVT) in Cirrhotics. In hospital complications and short term mortality were also followed up .

Methods Hospitalized cirrhotic patients were segregated into the PVT and non-PVT groups. Various clinical and laboratory parameters are included in the study . Indices possibly associated with PVT were measured . PVT was detected by both Doppler US and CECT abdomen . The SPSS soGware was used for all statistical analyses. All quantitative data were expressed as mean±standard deviation. Multivariate binary logistic regression was performed and the model was estimated using the step wise backward method.

Results 700 cirrhotic patients screened over 2 years period , 178 patients who full fill the inclusion criteria were included in our study. 56 (8%) had portal vein thrombosis. Majority of PVT were found in males aged 55±12 years. Most common presentation were gastrointestinal bleeding,abdominal distention, fever, jaundice, and hepatic encephalopathy . Most common site of portal vein thrombosis was PV trunk. NASH followed by alcohol related cirrhosis was the major etiology for cirrhosis in PVT.

Conclusions Some of the previously hypothesized risk factors for PVT, such as advanced age, male gender, smoking status, alcohol consumption, systemic hypertension, and D.M however were not associated with portal vein thrombosis in our study. Lower Blood platelet,Splenic diameter and Haemoglobulin levels were found statistically significant risk factor for portal vein thrombosis. There were no in hospital complications.

Publication History

Article published online:
14 April 2022