Quality of Colonic Preparations in the Real-World: Comparing of three agents, results of a large cohort

Aims Different bowel preparation formulas are used in colonic preparation before colonoscopy. The study aimed to investigate colonoscopy quality in three different colonoscopy preparation agents.

Methods Multi-center, large cohort, retrospective study included colonoscopies performed between 2016 and 2021 with data regarding the preparation agent and the quality of preparation. Multi-center study, data collected from seven Assuta endoscopy departments. Three preparation agents (polyethylene glycol (Moviprep), Sodium picosulfate with Magnesium citrate (picosalax), and Macrogols (Meroken). The quality grading of excellent, good, fair and poor preparation was used.

Results We included 206,964 patients who underwent colonoscopy,

13,117 patients used Moviprep, 184,181 used picosalax, and 9666 used Meroken. 38% of the Moviprep patients were 61 or older, compared to 37.2% and 65.2 for picosalax and meroken, p<0.001. Excellent colonic preparation was more common among patient prepared with moviprep compared to picosalax and meroken (12.3% vs 11% vs 5%, p<0.001), while good preparation was more common among patients prepared with picosalax with 64.3% compared to 58.2% and 61.5%. people aged 60 and younger had higher rates of excellent and good colonic preparation in all agents, while patients aged 61 and older had higher rates of fair and poor preparation grading.

Conclusions Differences in colonic preparation were found in different preparation agents; age 61 years and older were found to be associated with low quality of preparation; these should be considered in prescribing colonic preparation agents.

Conflicts of interest

Authors do not have any conflict of interest to disclose.

Publication History

Article published online:
15 April 2024