Prevalence of local recurrence following resection of esophagogastric neoplasia: analysis of factors related to endoscopic diagnosis

Aims The endoscopic follow-up after resection of esophagogastric neoplasms (EGN) lacks consensus due to the uncertain prevalence of local recurrence and its associated factors. The common recommendations include gastroscopy for subtotal gastrectomy cases and esophageal examination only when symptoms are present.

This study aims to determine the prevalence of recurrence post-resection and assess factors related to local recurrence in EGN.

Methods Observational, retrospective, experienced single-center study for the assessment of post-resection recurrence of EGN. Patients from the esophagogastric tumor registry who underwent surgical resection and endoscopic follow-up during the period (2013-2023) were included. Demographic characteristics and factors related to neoplastic disease were recorded. The prevalence of recurrence, radiological and endoscopic findings during follow-up were evaluated.

Results A total of 111 patients out of 122 with surgically resected EGN were included. Of these, 15.3% were esophageal, 9.9% esophagogastric junction, and 74.8% gastric. R0 resection was considered in 81.8% of patients, with the most frequent staging being T3 (40.4%) and N0 (63.2%). 68.5% received systemic treatment. Thirty-five recurrences occurred (31.5%), of which 5 (14.3%) were local and 22 (68.6%) were disseminated. Local recurrences occurred at a mean follow-up of 25.2 months (IQR 7.5-48.5). Only 1 of the cases of local recurrence was diagnosed by follow-up endoscopy. None of the analyzed factors (gastric metaplasia, type of surgery, staging, symptoms) were significantly associated with local recurrence.

Conclusions Local recurrence after resection of EGN is infrequent, and no factors have been found to be significantly related to it. These findings could be considered for recommendations regarding endoscopic follow-up after the resection of EGN.

Conflicts of interest

Authors do not have any conflict of interest to disclose.

Publikationsverlauf

Artikel online veröffentlicht:
15. April 2024