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Thromb Haemost 1973; 29(03): 722-729
DOI: 10.1055/s-0038-1648115
Original Article
Schattauer GmbH

Platelet Coagulant Activities and Clinical Severity in Haemophilia

Peter N. Walshi   *
1   Oxford Haemophilia Centre, Churchill Hospital, Oxford, and Lord Mayor Treloar College, Froyle, Alton, Hants
,
S. G Rainsford
1   Oxford Haemophilia Centre, Churchill Hospital, Oxford, and Lord Mayor Treloar College, Froyle, Alton, Hants
,
Rosemary Biggs
1   Oxford Haemophilia Centre, Churchill Hospital, Oxford, and Lord Mayor Treloar College, Froyle, Alton, Hants
› Author Affiliations
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

Assays for platelet coagulant activities concerned with the initiation and progress of intrinsic coagulation were done pair-wise in two groups of 16 haemophiliacs without detectable factor VIII. The patients in the ‘severe’ group had experienced 7.9-22.8 (mean 13.7) spontaneous haemorrhages per 100 days during an average of 431 days of observation, whereas those in the ‘mild’ group had bled 0-5.5 (mean 3.2) times per 100 days during an average of 282 days of observation. Contact product forming activity, collagen-induced coagulant activity and intrinsic factor-Xa forming activity were decreased in the severely-affected group and increased in the mildly affected group, whereas there was no great difference in platelet factor 3 activity between the two groups. Variations of platelet coagulant activities concerned with the initiation and early stages of intrinsic coagulation may influence clinical severity in haemophilia.

* Present address, Department of Medicine, Temple University, School of Medicine, Health Sciences Center, 3400 North Broad Street, Philadelphia, Pennsylvania 19140 U.S.A.


 

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