Synlett 2003(6): 0882-0884
DOI: 10.1055/s-2003-38755
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Phosphine-Free Suzuki-Miyaura Reactions Catalyzed by Bishydrazone-Pd-Complex

Takashi Mino*, Yoshiaki Shirae, Masami Sakamoto, Tsutomu Fujita
Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan
Fax: +81(43)2903401; e-Mail: tmino@planet.tc.chiba-u.ac.jp;
Further Information

Publication History

Received 4 March 2003
Publication Date:
17 April 2003 (online)

Abstract

Glyoxal bis(methylphenylhydrazone) 1 was prepared and examined as a ligand for the Suzuki-Miyaura cross-coupling reaction of aryl bromides and arylboronic acids. We found phosphine-free catalyst, such as Pd(OAc)2/hydrazone ligand 1 to be an efficient catalyst for a variety of substrates to produce the coupling products in good yields at room temperature.