Das belastungsinduzierte Lungenbluten – Nicht nur im Rennsport ein ernstzunehmendes Problem

Das belastungsinduzierte Lungenbluten ist eine ernstzunehmende Differenzialdiagnose bei Leistungsschwäche des Sportpferds in allen Disziplinen des Pferdesports. Die Früherkennung und die Erstellung individueller Behandlungs- und Managementpläne sind die Grundlagen für den Einsatz betroffener Pferde im Sport.

Publikationsverlauf

Artikel online veröffentlicht:
11. September 2023

• Literatur

• 1 Sullivan S, Hinchcliff K. Update on Exercise-Induced Pulmonary Hemorrhage. Vet Clin North Am: Equine Pract 2015; 31: 187-198 DOI: 10.1016/j.cveq.2014.11.011.
• 2 Gold JR, Knowles DP, Coffey T, Bayly WM. Exercise-Induced Pulmonary Hemorrhage in Barrel Racing Horses in the Pacific Northwest Region of the United States. J Vet Intern Med 2018; 32: 839-845 DOI: 10.1111/jvim.15066.
• 3 Da Silva KM, Otaka JNP, Gonçalves CAP, Silva EGA, de Alencar NX, Lessa DAB. Association between Exercise-Induced Pulmonary Hemorrhage and Inflammatory Airway Disease in Polo Ponies. J Equine Sci 2017; 28: 55-59
• 4 Tarancón I, Armengou L, Melendez-Lazo A, Pastor J, Ríos J, Jose-Cunilleras E. Prevalence of Exercise-Induced Pulmonary Hemorrhage in Competing Endurance Horses. J Am Vet Med Assoc 2019; 255: 710-715 DOI: 10.2460/javma.255.6.710.
• 5 Hinchcliff KW, Couetil LL, Knight PK, Morley PS, Robinson NE, Sweeney CR, Van Erck E. Exercise Induced Pulmonary Hemorrhage in Horses: American College of Veterinary Internal Medicine Consensus Statement. J Vet Intern Med 2015; 29: 743-758 DOI: 10.1111/jvim.12593.
• 6 Reed SM, Bayly WM, Sellon DC. Equine Internal Medicine. Elsevier Health Sciences; 2017
• 7 Bayly W. Exercise-Induced Pulmonary Hemorrhage – An Occupational Hazard of High-Speed Exercise. 2021. 30. 31
• 8 West JB, Mathieu-Costello O, Jones JH, Birks EK, Logemann RB, Pascoe JR, Tyler WS. Stress Failure of Pulmonary Capillaries in Racehorses with Exercise-Induced Pulmonary Hemorrhage. J Appl Physiol 1993; 75: 1097-1109
• 9 Maina JN, West JB. Thin and Strong! The Bioengineering Dilemma in the Structural and Functional Design of the Blood-Gas Barrier. Physiol Rev 2005; 85: 811-844 DOI: 10.1152/physrev.00022.2004.
• 10 Franklin SH, Van Erck-Westergren E, Bayly WM. Respiratory Responses to Exercise in the Horse: Respiratory Responses of Healthy Horses to Exercise. Equine Vet J 2012; 44: 726-732 DOI: 10.1111/j.2042-3306.2012.00666.x.
• 11 Manohar M. Pulmonary Vascular Pressures of Thoroughbreds Increase Rapidly and to a Higher Level with Rapid Onset of High-Intensity Exercise than Slow Onset. Equine Vet J 1994; 26: 496-499 DOI: 10.1111/j.2042-3306.1994.tb04057.x.
• 12 Manohar M, Goetz TE. Pulmonary Vascular Pressures of Exercising Thoroughbred Horses with and without Endoscopic Evidence of EIPH. J Appl Physiol 1996; 81: 1589-1593 DOI: 10.1152/jappl.1996.81.4.1589.
• 13 Williams KJ, Robinson NE, DeFeijter-Rupp H, Millerick-May M, Stack A, Hauptman J, Derksen FJ. Distribution of Venous Remodeling in Exercise-Induced Pulmonary Hemorrhage of Horses Follows Reported Blood Flow Distribution in the Equine Lung. J Appl Physiol 2013; 114: 869-878 DOI: 10.1152/japplphysiol.01170.2012.
• 14 Crispe EJ, Lester GD. Exercise-Induced Pulmonary Hemorrhage. Vet Clin North Am: Equine Pract 2019; 35: 339-350 DOI: 10.1016/j.cveq.2019.03.007.
• 15 Rocchigiani G, Verin R, Uzal FA, Singer ER, Pregel P, Ressel L, Ricci E. Pulmonary Bleeding in Racehorses: A Gross, Histologic, and Ultrastructural Comparison of Exercise-Induced Pulmonary Hemorrhage and Exercise-Associated Fatal Pulmonary Hemorrhage. Vet Pathol 2022; 59: 973-982 DOI: 10.1177/03009858221117859.
• 16 OʼCallaghan MW, Pascoe JR, Tyler WS, Mason DK. Exercise-Induced Pulmonary Haemorrhage in the Horse: Results of a Detailed Clinical, Post Mortem and Imaging Study. V. Microscopic Observations. Equine Vet J 1987; 19: 411-418 DOI: 10.1111/j.2042-3306.1987.tb02632.x.
• 17 McKane SA, Slocombe RF. Sequential Changes in Bronchoalveolar Cytology after Autologous Blood Inoculation. Equine Vet J 2010; 31: 126-130 DOI: 10.1111/j.2042-3306.1999.tb05202.x.
• 18 Williams KJ, Derksen FJ, Defeijter-Rupp HL, Robinson NE. Repeated Blood Instillation into the Airway of the Horse Does Not Cause Pulmonary Fibrosis: Pulmonary Response to Repeated Airway Instillation of Autologous Blood in Horses. Equine Vet J 2011; 43: 354-358 DOI: 10.1111/j.2042-3306.2010.00163.x.
• 19 Mahalingam-Dhingra A, Bedenice D, Mazan MR. Bronchoalveolar Lavage Hemosiderosis in Lightly Active or Sedentary Horses. J Vet Intern Med 2023; 37: 1243-1249
• 20 Hinchcliff KW, Jackson MA, Brown JA, Dredge AF, OʼCallaghan PA, McCaffrey JP, Morley PS, Slocombe RF, Clarke AF. Tracheobronchoscopic Assessment of Exercise-Induced Pulmonary Hemorrhage in Horses. American journal of veterinary research 2005; 66: 596-598
• 21 Hinchcliff KW, Jackson MA, Morley PS, Brown JA, Dredge AF, OʼCallaghan PA, McCaffrey JP, Slocombe RF, Clarke AF. Association between Exercise-Induced Pulmonary Hemorrhage and Performance in Thoroughbred Racehorses. J Am Vet Med Assoc 2005; 227: 768-774
• 22 Lo Feudo CM, Stucchi L, Stancari G, Alberti E, Conturba B, Zucca E, Ferrucci F. Associations between Exercise-Induced Pulmonary Hemorrhage (EIPH) and Fitness Parameters Measured by Incremental Treadmill Test in Standardbred Racehorses. Animals 2022; 12: 449
• 23 Lopez Sanchez CM, Kogan C, Gold JR, Sellon DC, Bayly WM. Relationship between Tracheobronchoscopic Score and Bronchoalveolar Lavage Red Blood Cell Numbers in the Diagnosis of Exercise‐induced Pulmonary Hemorrhage in Horses. J Vet Intern Med 2020; 34: 322-329
• 24 Hinchcliff KW. Counting Red Cells – Is It the Answer to EIPH?. Equine Vet J 2010; 32: 362-363 DOI: 10.2746/042516400777591084.
• 25 Bertram CA, Marzahl C, Bartel A, Stayt J, Bonsembiante F, Beeler-Marfisi J, Barton AK, Brocca G, Gelain ME, Gläsel A. et al. Cytologic Scoring of Equine Exercise-Induced Pulmonary Hemorrhage: Performance of Human Experts and a Deep Learning-Based Algorithm. Vet Pathol 2023; 60: 75-85 DOI: 10.1177/03009858221137582.
• 26 Depecker M, Richard EA, Pitel PH, Fortier G, Leleu C, Couroucé-Malblanc A. Bronchoalveolar Lavage Fluid in Standardbred Racehorses: Influence of Unilateral/Bilateral Profiles and Cut-off Values on Lower Airway Disease Diagnosis. Vet J 2014; 199: 150-156 DOI: 10.1016/j.tvjl.2013.10.013.
• 27 Depecker M, Couroucé-Malblanc A, Leleu C, Gennevieve V, Pitel PH, Richard E. Comparison of Two Cytological Methods for Detecting Pulmonary Haemorrhage in Horses. Vet Rec 2015; 177: 305 DOI: 10.1136/vr.103332.
• 28 Doucet MY, Viel L. Alveolar Macrophage Graded Hemosiderin Score from Bronchoalveolar Lavage in Horses with Exercise‐induced Pulmonary Hemorrhage and Controls. J Vet Intern Med 2002; 16: 281-286 DOI: 10.1892/0891-6640(2002)016<0281:amghsf>2.3.co;2.
• 29 Marzahl C, Aubreville M, Bertram CA, Stayt J, Jasensky AK, Bartenschlager F, Fragoso-Garcia M, Barton AK, Elsemann S, Jabari S. et al. Deep Learning-Based Quantification of Pulmonary Hemosiderophages in Cytology Slides. Sci Rep 2020; 10: 9795 DOI: 10.1038/s41598-020-65958-2.
• 30 Deutsche Reiterliche Vereinigung e.V.. 2021, FN Anti-Doping-Und Medikamentenkontroll-Regeln für den Pferdesport – ADMR. Im Intenet (Datum des Zugriffs: 07.07.2023): https://www.pferd-aktuell.de/shop/downloadable/download/sample/sample_id/29/
• 31 FEI Clean Sport. 2023, Equine Prohibited Substances List. Im Intenet (Datum des Zugriffs: 07.07.2023): https://inside.fei.org/sites/default/files/2023%2520Prohibited%2520Substances%2520List.pdf
• 32 Deutsche Reiterliche Vereinigung e.V.. 2021, Fairer Sport – Sicher und sauber durch die Turniersaison. Im Intenet (Datum des Zugriffs: 07.07.2023): https://www.pferd-aktuell.de/shop/downloadable/download/sample/sample_id/120/
• 33 Knych HK, Vale A, Wilson WD, Kass PH, Arthur RM, Jones JH. Pharmacokinetics of Furosemide Administered 4 and 24 Hours Prior to High-Speed Exercise in Horses. J Vet Pharmacol Therap 2018; 41: 224-229 DOI: 10.1111/jvp.12458.
• 34 Villarino NF, Lopez CM, Sams RA, Bayly WM. Pharmacokinetics of Furosemide in Thoroughbred Horses Subjected to Supramaximal Treadmill Exercise with and without Controlled Access to Water. BMC Vet Res 2019; 15: 275 DOI: 10.1186/s12917-019-2017-3.
• 35 Bonomo CCM, Michelotto PV, Viccino C, Barussi FCM, Fernandes WR. Occurrence of Exercise-Induced Pulmonary Haemorrhage in Show Jumping Horses. Vet J 2019; 248: 91-94 DOI: 10.1016/j.tvjl.2019.05.003.