Verification of the increase in concomitant dysplasia and cancer with the size of sessile serrated lesions

Daisuke Ohki; Yosuke Tsuji; Hiroyuki Hisada; Hideki Nakagawa; Satoru Mizutani; Kaori Oshio; Junichi Sato; Dai Kubota; Rina Cho; Yuko Miura; Hiroya Mizutani; Yoshiki Sakaguchi; Yu Takahashi; Seiichi Yakabi; Naomi Kakushima; Nobutake Yamamichi; Tetsuo Ushiku; Mitsuhiro Fujishiro

doi:10.1055/a-2246-0820

Endoscopy International Open, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Endosc Int Open 2024; 12(03): E448-E455
DOI: 10.1055/a-2246-0820

Original article

Verification of the increase in concomitant dysplasia and cancer with the size of sessile serrated lesions

Daisuke Ohki

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Yosuke Tsuji

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

²Next-Generation Endoscopic Computer Vision, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan (Ringgold ID: RIN13143)

,

Hiroyuki Hisada

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Hideki Nakagawa

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Satoru Mizutani

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Kaori Oshio

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Junichi Sato

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Dai Kubota

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Rina Cho

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Yuko Miura

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Hiroya Mizutani

²Next-Generation Endoscopic Computer Vision, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan (Ringgold ID: RIN13143)

,

Yoshiki Sakaguchi

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Yu Takahashi

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Seiichi Yakabi

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Naomi Kakushima

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Nobutake Yamamichi

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

,

Tetsuo Ushiku

³Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

,

Mitsuhiro Fujishiro

¹Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (Ringgold ID: RIN13143)

› Institutsangaben

Abstract

Background and study aims This study aimed to evaluate the relationship between sessile serrated lesion (SSL) size and the comorbidity rate of SSL with dysplasia (SSLD) and cancer in SSL (SSL-cancer).

Patients and methods This retrospective, single-center analysis identified SSL cases that underwent endoscopic resection between January 2015 and December 2022. The prevalence of SSL, SSLD, and SSL-cancer and their annual trends were assessed. The tumor diameter was stratified as 0 to 5 mm, 6 to 9 mm, 10 to 19 mm, and ≥ 20 mm in size. Furthermore, the frequency of SSL-D/SSL-cancer was determined in each group.

Results The prevalence of SSL was 2.9% (1328/45799). This prevalence was 1.8% (112/6192) in 2015 and 4.2% (230/5500) in 2022, indicating an increasing trend over time. A total of 1825 lesions were assessed: 1751 (96.0%), 55 (3.0%), 14 (0.8%), and 5 (0.3%) of lesions were SSL, SSL with low-grade dysplasia, SSL with high-grade dysplasia and SSL-cancer, respectively. Stratifying the SSLs by size: 0 to 5 mm, 5 to 9 mm, 10 to 19 mm, and ≥ 20 mm, SSLD and SSL-cancer rates were 2.3% (10/429), 2.4% (16/674), 5.3% (31/584), and 11.8% (16/136), respectively. SSLD and SSL-cancer were observed in 2.4% (26/1103) of small SSLs < 10 mm.

Conclusions In cases of SSL, the rate of SSLD and SSL-cancer increased as the lesion diameter increased. A certain rate of SSLD and SSL-cancer was observed even in small SSLs less than 5mm.

Keywords

Endoscopy Upper GI Tract - Endoscopic resection (ESD, EMRc, ...) - Endoscopy Lower GI Tract - Polyps / adenomas / ... - Colorectal cancer

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Referenzen

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