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Horm Metab Res 1974; 6(4): 289-292
DOI: 10.1055/s-0028-1093850
DOI: 10.1055/s-0028-1093850
Originals
© Georg Thieme Verlag KG Stuttgart · New York
Investigation of the Diuretic Effect of Glibenclamide in Healthy Subjects and in Patients with Pituitary and Nephrogenic Diabetes Insipidus
Further Information
Publication History
Publication Date:
08 January 2009 (online)
Abstract
Glibenclamide (G) had a diuretic effect during ad libitum fluid intake as well as during maximal sustained water diuresis in patients with pituitary diabetes insipidus. The diuretic effect could be demonstrated also in healthy subjects during maximal sustained water diuresis. No antagonism was found between small doses of lysine-vasopressin and G. Diuretic action of G seems not to be mediated through inhibition of the release or/and renal effect of antidiuretic hormone (ADH). An effect on the water reabsorbing mechanism not depending on ADH was supposed. Diuretic effect of G has important clinical implications.
Key words
Glibenclamide - Diabetes Insipidus - Diuretic Effect