Subscribe to RSS
DOI: 10.1055/s-0028-1103109
© Georg Thieme Verlag Stuttgart · New York
Die diabetische Nephropathie im Alter – Ist das therapeutisch Machbare auch erstrebenswert?
Diabetic nephropathy in elderlyPublication History
Publication Date:
05 November 2008 (online)
Die deutsche Bevölkerung wird zunehmend älter. Auch gibt es immer mehr Diabetes mellitus im Alter. Die diabetische Nephropathie ist die Hauptursache für Nierenversagen. Der rechtzeitigen Diagnostik mittels Mikroalbuminurie–Nachweis kommt neben der Bestimmung der Nierenfunktion entscheidende Bedeutung zu. Grundlagen der Behandlung sind die Kochsalzreduktion sowie die konsequente Blutdruckeinstellung. Die rechtzeitige Überweisung zum Nephrologen nutzt den Betroffenen. Die Nierenersatztherapie im Alter unterscheidet sich nicht wesentlich von der bei jüngeren Betroffenen. Entscheidend für die Behandlung der diabetischen Nephropathie ist die konsequente Vorbeugung.
The German population is growing in age. The incidence of diabetes mellitus in this population is growing, too. The diabetic nephropathy is the main cause for end stage renal failure. Important for the future development of this disease is the estimation of the kidney function and urinanalysis for microalbuminuria. Sodium restriction and a consistent antihypertensive therapy are the basis. The patient benefits from early referral to the nephrologist. Renal replacement therapy does not differ between younger and elder people. Prophylaxis is fundamental for the therapy of diabetic nephropathy.
Key words
Nephropathy - diabetes - old age microalbuminuria - sodium restriction - antihypertensive therapy
Literatur
- 1 Thefeld W.. Prevalence of diabetes mellitus in the adult German population. Gesundheitswesen. 1999; 61
- 2 Ayodele OE, Alebiosu CO, Salako BL.. Diabetic nephropathy – a review of the natural history, burden, risk factors and treatment. J Natl Med Assoc. 2004; 96 1445-1454
- 3 Janka H.. Hypertonie beim Diabetes mellitus. Diabetologie und Stoffwechsel. 2006; 1 188-189
- 4 Pfister M, Jakob S, Frey FJ, Niederer U. et al. . Judgment analysis in clinical nephrology. Am J Kidney Dis. 1999; 34 569-575
- 5 Frei U, Schober–Halstenberg H–J.. Nierenersatztherapie in Deutschland. QuaSi–Niere Jahresbericht 2006/ 2007. Berlin 2008
- 6 Amann K, Benz K.. Diabetes mellitus. Der Nephrologe. 2007; 2 319-324
- 7 Cockcroft DW, Gault MH.. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16 31-41
- 8 Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D.. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999; 130 461-470
- 9 Levey AS, Eckardt KU, Tsukamoto Y. et al. . Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005; 67 2089-2100
- 10 Robertson L, Waugh N, Robertson A.. Protein restriction for diabetic renal disease. Cochrane Database Syst Rev. 2007; 4
- 11 Ikizler TA, Wingard RL, Sun M, Harvell J, Parker RA, Hakim RM.. Increased energy expenditure in hemodialysis patients. J Am Soc Nephrol. 1996; 7 2646-2653
- 12 Ikizler TA, Hakim RM.. Nutrition in end–stage renal disease. Kidney Int. 1996; 50 343-357
- 13 Luft FC, Weinberger MH.. Heterogeneous responses to changes in dietary salt intake: the salt–sensitivity paradigm. Am J Clin Nutr. 1997; 65
- 14 Feldstein CA.. Salt intake, hypertension and diabetes mellitus. J Hum Hypertens. 2002; 16
- 15 Navis G, Faber HJ, De ZD, de Jong PE.. ACE inhibitors and the kidney. A risk–benefit assessment. Drug Saf. 1996; 15 200-211
- 16 Merker L, Scholz M.. The Consultation and Support Program DiaNe for People with Diabetic Nephropathy Reduces the Deterioration of the Kidney Function and Enhances the Patients Compliance. Diabetes. 2005; 54
- 17 Patel AB, Kostis JB, Wilson AC, Shea ML. et al. . Long–term fatal outcomes in subjects with stroke or transient ischemic attack: fourteen–year follow–up of the systolic hypertension in the elderly program. Stroke. 2008; 39 1084-1089
- 18 Erdine S, Ari O, Zanchetti A. et al. . ESH–ESC guidelines for the management of hypertension. Herz. 2006; 31 331-338
- 19 Gaede P, Vedel P, Larsen N, Jensen GV. et al. . Parving HH. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003; 348 383-393
- 20 Mogensen CE.. Natural history of cardiovascular and renal disease in patients with type 2 diabetes: effect of therapeutic interventions and risk modification. Am J Cardiol. 1998; 82
- 21 Cleveland DR, Jindal KK, Hirsch DJ, Kiberd BA.. Quality of prereferral care in patients with chronic renal insufficiency. Am J Kidney Dis. 2002; 40 30-36
- 22 Chow KM, Szeto CC, Law MC, Kwan BC. et al. . Impact of early nephrology referral on mortality and hospitalization in peritoneal dialysis patients. Perit Dial Int. 2008; 28 371-376
- 23 Taskapan H, Tam P, Au V. et al. . Improvement in eGFR in patients with chronic kidney disease attending a nephrology clinic. Int Urol Nephrol. 2008; 40 841-848
- 24 Orlando LA, Owen WF, Matchar DB.. Relationship between nephrologist care and progression of chronic kidney disease. N C Med J. 2007; 68 9-16
- 25 Lin CL, Wu MS, Hsu PY, Huang CC.. Improvement of clinical outcome by early nephrology referral in type II diabetics on hemodialysis. Ren Fail. 2003; 25 455-464
- 26 Goransson LG, Bergrem H.. Consequences of late referral of patients with end–stage renal disease. J Intern Med. 2001; 250
- 27 Winkelmayer WC, Owen Jr. WF, Levin R, Avorn J.. A propensity analysis of late versus early nephrologist referral and mortality on dialysis. J Am Soc Nephrol. 2003; 14 486-492
- 28 Mann JF, Schmieder RE, McQueen M. et al. . Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double–blind, controlled trial. Lancet. 2008; 372 547-553
- 29 The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. . Major Outcomes in High–Risk Hypertensive Patients Randomized to Angiotensin–Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid–Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002; 288 2981-2997
- 30 Merker L.. Antihypertensive Therapy and Diabetic Nephropathy. Der Nephrologe. 2007; 2 340-349
- 31 Baigent C, Landry M.. Study of Heart and Renal Protection (SHARP). Kidney Int Suppl. 2003; 84
- 32 Bonucchi D, D'Amelio A, Grosoli M, Baraldi A, Cappelli G.. Vascular access for haemodialysis: from surgical procedure to an integrated therapeutic approach. Nephrol Dial Transplant. 1998; 13 78-81
- 33 Tapson JS, Rodger RS, Mansy H, Elliott RW. et al. . Renal replacement therapy in patients aged over 60 years. Postgrad Med J. 1987; 63 1071-1077
- 34 Ahmed S, Addicott C, Qureshi M, Pendleton N, Clague JE, Horan MA.. Opinions of elderly people on treatment for end–stage renal disease. Gerontology. 1999; 45 156-159
- 35 Harris SA, Lamping DL, Brown EA, Constantinovici N.. Clinical outcomes and quality of life in elderly patients on peritoneal dialysis versus hemodialysis. Perit Dial Int. 2002; 22 463-470
- 36 Grun RP, Constantinovici N, Normand C, Lamping DL.. Costs of dialysis for elderly people in the UK. Nephrol Dial Transplant. 2003; 18 2122-2127
- 37 Lamping DL, Constantinovici N, Roderick P. et al. . Clinical outcomes, quality of life, and costs in the North Thames Dialysis Study of elderly people on dialysis: a prospective cohort study. Lancet. 2000; 356 1543-1550
Korrespondenz
Dr. med. Ludwig Merker
Diabetes– und Nierenzentrum Dormagen
Florastr. 8
41539 Dormagen
Email: merker@dialyse-dormagen.de