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Exp Clin Endocrinol Diabetes 1985; 86(4): 17-25
DOI: 10.1055/s-0029-1210468
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effects of High Doses of Oestrogens and Androgens on Lipoproteins: Observations in the Treatment of Excessive Growth with Sexual Hormones

G. K. Hinkel1 , M. Hanefeld2 , W. Jaross3 , W. Leonhardt2 , A. Trübsbach3
  • 1Children's Hospital (Head: Prof. Dr. H.-J. Dietzsch), Medical Academy “Carl Gustav Carus”, Dresden/GDR
  • 2Medical Clinic (Head: Prof. Dr. H. Haller), Medical Academy “Carl Gustav Carus”, Dresden/GDR
  • 3Institute of Clinical Chemistry and Laboratory Diagnostics (Head: Prof. Dr. W. Jaroß), Medical Academy “Carl Gustav Carus”, Dresden/GDR
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

In a prospective study we investigated the changes of lipoprotein metabolism under therapy with high doses of oestrogens or androgens, applied to stop the excessive growth of very tall girls or boys.

Therapy with 2 mg ethinyl oestradiol sulfonate per week for one year in 11 girls resulted in an increase in serum triglycerides, which was reversible after cessation, and a minimal rise of total cholesterol and HDL-cholesterol in the phase of adaptation to this treatment. Therapy with 1000 mg testosterone oenanthate per month for one year lead to a fall of triglycerides and HDL cholesterol.

These changes are considered as a regulative phenomenon, without consequences for the application of the high dosage therapy with these steroid hormones in the treatment of excessive growth.

Key words

Lipoproteins - Tall children - Therapy with Oestrogens - Therapy with Androgens