The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype

J. A. Maassen; J. J. Jansen; T. Kadowaki; J. M. W. van den Ouweland; L. M. 't Hart; H. H. P. J Lemkes

doi:10.1055/s-0029-1211444

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Exp Clin Endocrinol Diabetes 1996; 104(3): 205-211
DOI: 10.1055/s-0029-1211444

Review

The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype

J. A. Maassen¹ , J. J. Jansen² , T. Kadowaki³ , J. M. W. van den Ouweland¹ , L. M. 't Hart, H. H. P. J Lemkes²

¹Department of Medical Biochemistry, Leiden University
²Department of Endocrinology and Metabolic Diseases, University Hospital, Leiden University, The Netherlands
³Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan

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Publication History

Publication Date:
15 July 2009 (online)

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Summary

Diabetes mellitus comprises a number of diseases with hyperglycemia as hallmark. Currently, multiple genetic factors are being recognized which contribute to the development of diabetes or which may modulate its clinical expression. This review presents an overview of our current knowledge on a diabetic subtype which associates with a single mutation in mitochondrial DNA. Based on the triad of Maternal Inheritance, Diabetes and Deafness we propose the name Maternally Inherited Diabetes and Deafness (MIDD) for this syndrome. In Northwestern Europe MIDD affects approximately 1.3% of all diabetic individuals.

Key words

Diabetes - deafness - mitochondria - genetics