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Synfacts 2009(12): 1315-1315
DOI: 10.1055/s-0029-1218333
DOI: 10.1055/s-0029-1218333
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Tamiflu
M. Karpf*, R. Trussardi*
F. Hoffmann-La Roche Ltd., Basel, Switzerland
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. November 2009 (online)
Significance
Tamiflu is active against H5N1 avian influenza and H1N1 swine influenza. Several hundred metric tons of it have been stockpiled in case of a pandemic. The unoptimized route depicted is shorter than the current production route starting from shikimic acid (A).