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DOI: 10.1055/s-0030-1249974
© Georg Thieme Verlag KG Stuttgart · New York
Immunosuppressive Sesquiterpenes from Buddleja daviddi
Publikationsverlauf
received January 13, 2010
revised April 1, 2010
accepted April 26, 2010
Publikationsdatum:
26. Mai 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201016/lookinside/thumbnails/10.1055-s-0030-1249974-1.jpg)
Abstract
Six new sesquiterpenes, 2,6(12),10-humulatrien-7β-ol-1-one (1), 2α-acetoxy-5α-methoxy-enantio-caryophylla-8(15)-en-3-one (2), 2α-acetoxy-5α-hydroxy-enantio-caryophylla-8(15)-en-3-one (3), 2α-acetoxy-4β,5α-hydroxy-enantio-caryophylla-8(15)-en-3-one (4), 2α-acetoxy-4β,5β-hydroxy-enantio-caryophylla-8(15)-en-3-one (5), 2β-acetoxy-4-caryophyllen-8β-ol-3-one (6), and nineteen known compounds were isolated from the ethanol extract of Buddleja daviddi. The structures were elucidated by spectroscopic methods. Compounds 8–11, 14, 16, 17, and 20 showed significant immunosuppressive activities, and 8–11 and 14 were cytotoxic on HeLa and L929 cell lines.
Key words
Buddleja daviddi - Loganiaceae - humulane sesquiterpene - caryophyllane sesquiterpene - immunosuppressive activity - cytotoxic activity
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Dr. Hong Quan Duan
School of Pharmaceutical Sciences
Research Center of Basic Medical Sciences
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
People's Republic of China
Telefon: + 86 22 23 54 20 18
Fax: + 86 22 23 54 27 75
eMail: duanhq@tijmu.edu.cn