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Synfacts 2010(9): 1043-1043
DOI: 10.1055/s-0030-1257947
DOI: 10.1055/s-0030-1257947
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Polycyclizations Catalyzed by Gold(I)
S. G. Sethofer, T. Mayer, F. D. Toste*
University of California, Berkeley, USA
Further Information
Publication History
Publication Date:
23 August 2010 (online)
Significance
Polycyclization reactions have a rich history of providing complex polycyclic scaffolds from linear precursors (see Review below). While in the past an emphasis has been placed on studying the diastereoselectivity, recent work has focused on asymmetric polycyclizations. The authors present a highly enantioselective gold(I)-catalyzed polycyclization initiated by an initial 6-exo-dig of enyne substrates.
Review: R. A. Yoder, J. N. Johnston Chem. Rev. 2005, 105, 4730-4756.