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Synfacts 2011(1): 0008-0008  
DOI: 10.1055/s-0030-1259132
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Spongidepsin

Contributor(s): Steven V. Ley, Sean Newton
Y. Zhu, A. Loudet, K. Burgess*
Texas A&M University, College Station, USA
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Publikationsverlauf

Publikationsdatum:
21. Dezember 2010 (online)

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Significance

(-)-Spongidepsin is a polyketide natural product isolated from the Vanuatu marine sponge Spongia sp. It exhibits cytotoxic and anti-proliferative activity against certain cancer cell lines. (-)-Spongidepsin contains a 13-membered cyclodepsipeptide ring, a terminal acetylene, and five stereocenters.