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Synfacts 2011(5): 0464-0464  
DOI: 10.1055/s-0030-1259787
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Bryostatin 1

Contributor(s): Steven V. Ley, Kimberley A. Roper
G. E. Keck*, Y. B. Poudel, T. J. Cummins, A. Rudra, J. A. Covel
University of Utah, Salt Lake City, USA
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

Bryostatin 1 is a marine pyran ­isolated from B. neritina. The family has become popular synthetic targets due to their molecular complexity as well as their activity against a range of cancers and potential activity against Alzheimer’s disease. There have been six syntheses of members of the bryostatin family; however, this is the first synthesis of bryostatin 1 using a very convergent strategy with a longest linear sequence of 30 steps.