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Synfacts 2011(5): 0517-0517  
DOI: 10.1055/s-0030-1259864
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Rhodium-Catalyzed Allylic C-H Activation

Contributor(s): Hisashi Yamamoto, Patrick Brady
Q. Li, Z.-X. Yu*
Peking University, Beijing, P. R. of China
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Publikationsdatum:
15. April 2011 (online)

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Significance

The rhodium-phosphoramidite complex allows for activation of an allylic C-H bond and addition to a conjugated diene, generating two contiguous stereocenters, one of which is quaternary. The reaction proceeds with high ­diastereo- and enantiocontrol.